PDE9A Antibody (E-2): sc-271754

PDE9A Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects phosphodiesterase 9A (PDE9A) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE9A is a 593 amino acid protein that plays a crucial role in signal transduction by regulating intracellular concentration of cyclic nucleotides, particularly exhibiting a high affinity for cyclic guanosine monophosphate (cGMP). This regulation influences various physiological processes, including cardiovascular function and neuronal signaling. PDE9A is predominantly expressed in tissues such as brain, kidney, spleen, colon, heart, and placenta, with highest levels found in brain, where PDE9A is believed to be involved in cognitive functions and mood regulation. PDE9A is composed of an N-terminal regulatory domain and a C-terminal catalytic domain, which contains two potential divalent metal sites essential for enzymatic activity. Notably, PDE9A interaction with other proteins, such as phosphodiesterase 5A, may further modulate function and impact signaling pathways, making PDE9A a significant target for research in neuropsychiatric disorders, including affective bipolar disorder. Anti-PDE9A antibody (E-2) is an invaluable tool for researchers aiming to explore these intricate roles in health and disease.

The preferred PDE9A antibody is PDE9A Antibody (D-7): sc-376271.