MYBPC3 Antibody (G-2): sc-166081

MYBPC3 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects MYBPC3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MYBPC3, or myosin-binding protein C, cardiac, plays a crucial role in regulating cardiac muscle contraction by modulating the interaction between myosin and actin filaments. MYBPC3 is primarily located in the crossbridge-bearing zone of the A bands in vertebrate striated muscle, where MYBPC3 contributes to the structural integrity and functional dynamics of the sarcomere. Precise localization of MYBPC3 is vital for effective cardiac function, ensuring contractile proteins are properly organized and can respond to regulatory signals, such as phosphorylation by cAMP-dependent protein kinase (PKA) during adrenergic stimulation. Dysregulation or mutations in MYBPC3 can lead to significant cardiac disorders, including familial hypertrophic cardiomyopathy type 4, characterized by ventricular hypertrophy, which underscores MYBPC3′s importance in maintaining heart health. MYBPC3 is located on chromosome 11p11.2, and understanding MYBPC3′s function and interactions is essential for developing therapeutic strategies for related cardiac conditions.

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MYBPC3 Antibody (G-2) References:

1. From genotype to phenotype: a longitudinal study of a patient with hypertrophic cardiomyopathy due to a mutation in the MYBPC3 gene.  |  Jacques, A., et al. 2008. J Muscle Res Cell Motil. 29: 239-46. PMID: 19219553
2. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.  |  Barefield, D., et al. 2015. J Mol Cell Cardiol. 79: 234-43. PMID: 25463273
3. Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities.  |  Judge, DP., et al. 2015. J Cardiovasc Dev Dis. 2: 48-65. PMID: 26819945
4. Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.  |  Singh, SR., et al. 2017. Circ Heart Fail. 10: PMID: 29021349
5. MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.  |  O'Leary, TS., et al. 2019. J Mol Cell Cardiol. 127: 165-173. PMID: 30550750
6. Cryptic Splice-Altering Variants in MYBPC3 Are a Prevalent Cause of Hypertrophic Cardiomyopathy.  |  Lopes, LR., et al. 2020. Circ Genom Precis Med. 13: e002905. PMID: 32396390
7. An interesting Mybpc3 heterozygous mutation associated with bicuspid aortic valve.  |  Zhao, X., et al. 2020. Transl Pediatr. 9: 610-618. PMID: 33209723
8. Generation of two iPSC lines from hypertrophic cardiomyopathy patients carrying MYBPC3 and PRKAG2 variants.  |  Manhas, A., et al. 2022. Stem Cell Res. 61: 102774. PMID: 35413566
9. A Novel Loss-of-function Mutation in MYBPC3 Causes Familial Hypertrophic Cardiomyopathy with Extreme Intrafamilial Phenotypic Heterogeneity.  |  Peng, Y., et al. 2022. Balkan J Med Genet. 25: 71-78. PMID: 36880031
10. Identification of Two Homozygous Variants in MYBPC3 and SMYD1 Genes Associated with Severe Infantile Cardiomyopathy.  |  Szulik, MW., et al. 2023. Genes (Basel). 14: PMID: 36980931

The preferred MYBPC3 antibody is MYBPC3 Antibody (E-7): sc-137180.