Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues. Myotonic dystrophy kinase-related Cdc42-binding (DMPK-like) kinases-α and β (MRCK-α, β) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle myosin light chain and influences actin-myosin contractility. MRCK-α can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/cofilin and to Actin cytoskeletal reorganization. MRCK-α can also influence neurite outgrowth promoted by Cdc42 and Rac.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MRCKβ (A-2) | sc-390127 | 200 µg/ml | $316.00 | |||
MRCKβ (A-2): m-IgG Fc BP-HRP Kit | sc-540760 | 200 µg Ab; 10 µg BP | $354.00 | |||
MRCKβ (A-2): m-IgG1 BP-HRP Kit | sc-542353 | 200 µg Ab; 20 µg BP | $354.00 | |||
MRCKβ (A-2) peptide neutralisant | sc-390127 P | 100 µg/0.5 ml | $68.00 |