Anticorps Lefty (F-11): sc-166708

The TGFβ superfamily is composed of numerous growth and differentiation factors, including transforming growth factor (TGF) 1, 2 and 3; growth/differ-entiation factor (GDF) 1-9; Mullerian inhibiting substance (MIS); bone morpho-genic protein (BMP) 2-8; glial cell line-derived neurotrophic factor (GDNF); inhibins α, β-A, β-B and β-C; Lefty and Nodal. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. Lefty-A and Lefty-B are homologues of murine Lefty-1 and Lefty-2. Lefty-1 is required for left-right axis determination as a regulator of Lefty-2 and Nodal. It is a secreted protein expressed on the left side of developing embryos. The expression of Lefty-1 is mostly in the prospective floor plate (PFP), although weak expression can be seen in the lateral-plate mesoderm (LPM). It is involved in establishing left-right asymmetry of the organ systems of mammals. Lefty-A plays a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium.

L'anticorps Lefty préféré est l'Anticorps Lefty (D-6): sc-365845.