KLC2 Antibody (F-11): sc-515506
- KLC2 Antibody (F-11) is a mouse monoclonal IgG2b κ KLC2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 45-62 near the N-terminus of KLC2 of human origin
- KLC2 Antibody (F-11) is recommended for detection of KLC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KLC2 Antibody (F-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KLC2 Antibody (F-11) for WB applications. These reagents are now offered in bundles with KLC2 Antibody (F-11) (see ordering information below).
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KLC2 Antibody (F-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects KLC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KLC2 (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Kinesin light chain 2 (KLC2) is a vital component of the kinesin motor protein family, which is essential for intracellular transport, playing a significant role in the movement of organelles, vesicles, and macromolecular complexes within cells. KLC2 is composed of 622 amino acids and features six tetratricopeptide repeats (TPR), which are crucial for protein-protein interactions. KLC2 exists in an oligomeric complex with two light chains and two heavy chains, facilitating the coupling of organelle transport to ATPase activity, thereby ensuring efficient cellular function. KLC2 is involved in critical cellular processes such as cell division and membrane trafficking, including endocytosis and transcytosis. The gene encoding KLC2 is located on human chromosome 11, a region that contains over 1,400 genes and represents nearly 4% of the human genome, highlighting its significance in cellular biology and potential implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLC2 Antibody (F-11) References:
- Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. | Rahman, A., et al. 1999. J Cell Biol. 146: 1277-88. PMID: 10491391
- Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. | Bowman, AB., et al. 2000. Cell. 103: 583-94. PMID: 11106729
- Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. | DeBoer, SR., et al. 2008. Biochemistry. 47: 4535-43. PMID: 18361505
- Insulin-induced GLUT4 movements in C2C12 myoblasts: evidence against a role of conventional kinesin motor proteins. | Takazawa, K., et al. 2008. Kobe J Med Sci. 54: E14-22. PMID: 18772605
- Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. | Dhakal, BK. and Mulvey, MA. 2009. J Biol Chem. 284: 446-454. PMID: 18996840
- Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. | Rahman, A., et al. 1998. J Biol Chem. 273: 15395-403. PMID: 9624122
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLC2 Antibody (F-11) | sc-515506 | 200 µg/ml | $322.00 | |||
KLC2 Antibody (F-11): m-IgGκ BP-HRP Bundle | sc-525075 | 200 µg Ab, 40 µg BP | $361.00 | |||
KLC2 Antibody (F-11): m-IgG2b BP-HRP Bundle | sc-549209 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLC2 Antibody (F-11) AC | sc-515506 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KLC2 Antibody (F-11) HRP | sc-515506 HRP | 200 µg/ml | $322.00 | |||
KLC2 Antibody (F-11) FITC | sc-515506 FITC | 200 µg/ml | $336.00 | |||
KLC2 Antibody (F-11) PE | sc-515506 PE | 200 µg/ml | $349.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 488 | sc-515506 AF488 | 200 µg/ml | $364.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 546 | sc-515506 AF546 | 200 µg/ml | $364.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 594 | sc-515506 AF594 | 200 µg/ml | $364.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 647 | sc-515506 AF647 | 200 µg/ml | $364.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 680 | sc-515506 AF680 | 200 µg/ml | $364.00 | |||
KLC2 Antibody (F-11) Alexa Fluor® 790 | sc-515506 AF790 | 200 µg/ml | $364.00 | |||
KLC2 (F-11) Neutralizing Peptide | sc-515506 P | 100 µg/0.5 ml | $69.00 |