eotaxin Antibody (G-12): sc-373764
- eotaxin Antibody (G-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 71-96 at the C-terminus of eotaxin of human origin
- recommended for detection of eotaxin of mouse, rat and human origin by WB, IP, IF and ELISA
- See MCP-1-4/eotaxin (B-2): sc-377082 for eotaxin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for eotaxin Antibody (G-12) for WB applications. These reagents are now offered in bundles with eotaxin Antibody (G-12) (see ordering information below).
eotaxin Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects eotaxin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Eotaxin, also known as eotaxin-1, is a crucial member of the C-C or β family of chemokines, distinguished by its pair of adjacent cysteine residues, and plays a significant role in the immune response by acting as a potent chemoattractant for eosinophils. The importance of eotaxin lies in its involvement in various allergic conditions, including bronchial asthma, dermatitis, conjunctivitis, and potentially inflammatory bowel disease, where eosinophilia is a prominent feature. Eotaxin exerts its effects by binding to the CKR-3 receptor, which is expressed on the surface of primary eosinophils and is known to have high affinity for eotaxin, as well as for other chemokines like RANTES and MCP-3. Notably, CKR-3 also functions as a co-receptor for a restricted subset of viruses, highlighting the multifaceted role of eotaxin in both immune responses and viral interactions. anti-eotaxin antibody (G-12) is an essential tool for researchers studying the mechanisms of eosinophil recruitment and the pathophysiology of allergic diseases.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
eotaxin Antibody (G-12) References:
- The MCP/eotaxin subfamily of CC chemokines. | Van Coillie, E., et al. 1999. Cytokine Growth Factor Rev. 10: 61-86. PMID: 10379912
- Eotaxin and the attraction of eosinophils to the asthmatic lung. | Conroy, DM. and Williams, TJ. 2001. Respir Res. 2: 150-6. PMID: 11686879
- From airway inflammation to inflammatory bowel disease: eotaxin-1, a key regulator of intestinal inflammation. | Adar, T., et al. 2014. Clin Immunol. 153: 199-208. PMID: 24786916
- Eotaxin Augments Calcification in Vascular Smooth Muscle Cells. | Raghuraman, G., et al. 2017. J Cell Biochem. 118: 647-654. PMID: 27681294
- Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders. | Teixeira, AL., et al. 2018. Front Psychiatry. 9: 241. PMID: 29962972
- Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. | Wakabayashi, K., et al. 2021. Sci Rep. 11: 7937. PMID: 33846499
- Eotaxin-1 Levels in Patients with Myocardial Infarction. | Kalayci, M. and Gul, E. 2022. Clin Lab. 68: PMID: 35254015
- Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration. | Fan, Z., et al. 2022. Cell Death Dis. 13: 495. PMID: 35614068
- Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications. | Nazarinia, D., et al. 2022. Acta Neurol Belg. 122: 865-869. PMID: 35690992
- Regulation of eotaxin expression in skin allergic diseases. | Peng, C., et al. 2022. Postepy Dermatol Alergol. 39: 565-579. PMID: 35950112
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eotaxin Antibody (G-12) | sc-373764 | 200 µg/ml | $322.00 | |||
eotaxin Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-540396 | 200 µg Ab; 10 µg BP | $361.00 | |||
eotaxin Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-542094 | 200 µg Ab; 20 µg BP | $361.00 | |||
eotaxin (G-12) Neutralizing Peptide | sc-373764 P | 100 µg/0.5 ml | $69.00 |