CD34 Antibody (ICO115): sc-7324
- CD34 Antibody (ICO115) is a mouse monoclonal IgG1 κ CD34 antibody, cited in 234 publications, provided at 200 µg/ml
- raised against blast cells of a chronic myeloid leukemia patient
- CD34 Antibody (ICO115) is recommended for detection of CD34 of mouse, rat and human origin by WB, IP, IF and FCM
- CD34 Antibody (ICO115) is available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 405 for IF, IHC(P) and FCM
- available conjugated to either PerCP or Alexa Fluor® 405 for IF, IHC(P) and FCM
- m-IgG1 BP-HRP is the preferred secondary detection reagent for CD34 Antibody (ICO115) for WB applications. This reagent is now offered in a bundle with CD34 Antibody (ICO115) (see ordering information below).
QUICK LINKS
SEE ALSO...
CD34 Antibody (ICO115) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD34 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD34 (ICO115) antibody is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD34 is a heavily glycosylated transmembrane glycoprotein that plays a crucial role in identifying and isolating hematopoietic stem and progenitor cells, as CD34 is predominantly expressed on their surface. This expression is particularly significant because CD34 serves as a marker for the most primitive stem cells, which are essential for maintaining hematopoiesis and tissue regeneration. As these stem cells differentiate into lineage-committed progenitors, CD34 expression gradually diminishes, highlighting CD34′s importance in stem cell biology and potential therapeutic applications. CD34 is found on small-vessel endothelial cells and certain cells in fetal and adult nervous tissue, further underscoring CD34′s diverse roles in various biological contexts. The cytoplasmic domain of CD34 contains consensus sites for phosphorylation by activated protein kinase C and other kinases, which may influence signaling pathways critical for cell adhesion and migration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD34 Antibody (ICO115) References:
- Comparison of CD34 and monocyte-derived dendritic cells from mobilized peripheral blood from cancer patients. | Syme, R., et al. 2005. Stem Cells. 23: 74-81. PMID: 15625124
- CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. | Drew, E., et al. 2005. Immunity. 22: 43-57. PMID: 15664158
- Tumor skewing of CD34+ cell differentiation from a dendritic cell pathway into endothelial cells. | Young, MR. and Cigal, M. 2006. Cancer Immunol Immunother. 55: 558-68. PMID: 16025265
- Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. | Krause, DS., et al. 1994. Blood. 84: 691-701. PMID: 7519070
- CD34+ positive haemopoietic cells: biology and clinical applications. | Holyoake, TL. and Alcorn, MJ. 1994. Blood Rev. 8: 113-24. PMID: 7524841
- Expression of CD34 in endothelial cells, hematopoietic progenitors and nervous cells in fetal and adult mouse tissues. | Lin, G., et al. 1995. Eur J Immunol. 25: 1508-16. PMID: 7542195
- Selectin-carbohydrate interactions and the initiation of the inflammatory response. | Lasky, LA. 1995. Annu Rev Biochem. 64: 113-39. PMID: 7574477
- Cell adhesion receptors and early mammalian heart development: an overview. | Buck, CA., et al. 1993. C R Acad Sci III. 316: 838-59. PMID: 8076214
- Platelet endothelial cell adhesion molecule (CD31). | DeLisser, HM., et al. 1993. Curr Top Microbiol Immunol. 184: 37-45. PMID: 8313722
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD34 Antibody (ICO115) | sc-7324 | 200 µg/ml | $322.00 | |||
CD34 Antibody (ICO115): m-IgG1 BP-HRP Bundle | sc-531628 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD34 Antibody (ICO115) AC | sc-7324 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD34 Antibody (ICO115) FITC | sc-7324 FITC | 200 µg/ml | $336.00 | |||
CD34 Antibody (ICO115) PE | sc-7324 PE | 200 µg/ml | $349.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 488 | sc-7324 AF488 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 546 | sc-7324 AF546 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 594 | sc-7324 AF594 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 647 | sc-7324 AF647 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 680 | sc-7324 AF680 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 790 | sc-7324 AF790 | 200 µg/ml | $364.00 | |||
CD34 Antibody (ICO115) Alexa Fluor® 405 | sc-7324 AF405 | 200 µg/ml | $364.00 |