CD34 Antibody (D-6): sc-133082

CD34 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects CD34 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD34 is a heavily glycosylated, transmembrane glycoprotein that plays a crucial role in the identification and isolation of hematopoietic stem and progenitor cells, as CD34 is predominantly expressed on their surface. CD34 is essential for maintaining the stem cell niche and facilitating cell adhesion, which is vital for the proper functioning of the hematopoietic system. Notably, CD34 expression is highest in the most primitive stem cells and diminishes as these cells differentiate into lineage-committed progenitors, making CD34 a key marker for stem cell research and therapeutic applications. Additionally, the cytoplasmic domain of CD34 contains consensus sites for phosphorylation by activated protein kinase C, as well as serine, threonine, and tyrosine phosphorylation sites, which are important for signaling pathways that regulate cell growth and differentiation. Anti-CD34 antibody (D-6) is an invaluable tool for researchers studying stem cell biology, vascular development, and various hematological disorders.

The preferred CD34 antibody is CD34 Antibody (ICO115): sc-7324.