Olr203 Activateurs
Chemical activators of Olr203 can engage in various cellular mechanisms to ensure its activation. Calcium ionophore A23187 and ionomycin function as ionophores that facilitate the increase of intracellular calcium levels, which is a common intracellular signal that can lead to the activation of Olr203. The elevation of intracellular calcium can result from the activity of BAY K8644 as well, which selectively opens L-type calcium channels. Once inside the cell, calcium ions can bind to Olr203 or activate calcium-dependent kinases that can phosphorylate and activate Olr203, suggesting a direct influence on the protein's activity. Similarly, thapsigargin serves to increase cytosolic calcium by inhibiting the calcium pumps of the sarcoplasmic and endoplasmic reticulum, thwarting their ability to sequester calcium, thereby leading to the activation of calcium-sensitive pathways that include Olr203.
Additionally, forskolin raises cyclic AMP (cAMP) levels, which activates protein kinase A (PKA), and PKA can target Olr203 for phosphorylation, leading to its activation. Phorbol 12-myristate 13-acetate (PMA) and Diacylglycerol (DiC8) operate through protein kinase C (PKC), with PMA being a direct activator and DiC8 acting as a diacylglycerol analog to stimulate PKC which, in turn, can phosphorylate and activate Olr203. Anisomycin, by activating stress-activated protein kinases, can also lead to the phosphorylation and subsequent activation of Olr203. Inhibition of dephosphorylation can maintain Olr203 in an active state, and chemicals such as Okadaic Acid and Calyculin A inhibit protein phosphatases 1 and 2A, which would otherwise dephosphorylate and deactivate Olr203. Chelerythrine Chloride, although a PKC inhibitor, can induce changes that lead to Olr203 activation, possibly through compensatory mechanisms within the cell signaling network. Furthermore, Bryostatin 1 modulates PKC, which can lead to the phosphorylation and hence activation of Olr203, highlighting the diverse array of chemical interactions that can regulate the activity state of Olr203.
You've reached your subscription limit. You can still send messages but due to high usage responses may degrade or slow down.
VOIR ÉGALEMENT...
Items 1 to 10 of 11 total
Afficher:
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Ce produit chimique augmente les niveaux de calcium intracellulaire qui peuvent activer Olr203 en induisant des changements de conformation ou en activant des kinases dépendantes du calcium qui phosphorylent et activent Olr203. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
L'Ionomycine agit comme un ionophore calcique facilitant l'afflux d'ions calcium, ce qui conduit à l'activation de l'Olr203 par des changements dans les concentrations de calcium qui peuvent activer des voies de signalisation intracellulaires apparentées. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 est un agoniste des canaux calciques de type L qui provoque l'ouverture de ces canaux, ce qui permet aux ions calcium de pénétrer dans la cellule et d'activer Olr203 en modifiant les niveaux de calcium intracellulaire. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
La thapsigargin inhibe l'ATPase Ca2+ du réticulum sarcoplasmique/endoplasmique (SERCA), entraînant une augmentation des niveaux de calcium cytosolique qui peut activer Olr203, car la protéine est sensible aux changements de concentration des ions calcium. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
La PMA active la protéine kinase C (PKC) qui peut alors phosphoryler et activer Olr203. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DiC8 agit comme un analogue synthétique du diacylglycérol, un activateur direct de la PKC, qui à son tour peut phosphoryler et activer Olr203. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
L'anisomycine active les protéines kinases activées par le stress, qui peuvent phosphoryler Olr203, entraînant son activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
L'acide okadaïque inhibe les protéines phosphatases 1 et 2A, empêchant la déphosphorylation des protéines, ce qui maintiendrait Olr203 dans un état phosphorylé et actif. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
La caliculine A, comme l'acide okadaïque, est un puissant inhibiteur des protéines phosphatases 1 et 2A et, en inhibant le processus de déphosphorylation, elle peut maintenir Olr203 dans un état activé. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Le chlorure de chélérythrine, un inhibiteur de la PKC, peut entraîner des changements dans les états de phosphorylation au sein de la cellule, ce qui peut entraîner par inadvertance l'activation d'Olr203. | ||||||