Date published: 2026-5-23

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HDAC Substrates

Santa Cruz Biotechnology now offers a broad range of HDAC substrates for use in various applications. HDAC substrates, short for histone deacetylase substrates, are crucial biochemical tools used in epigenetics and chromatin biology research. These substrates are designed to interact with histone deacetylases (HDACs), enzymes that remove acetyl groups from histone proteins, thereby influencing gene expression by altering chromatin structure. In scientific research, HDAC substrates serve as key components in assays that measure HDAC activity, enabling researchers to study the mechanisms of gene regulation and epigenetic modifications. By providing insights into the dynamic nature of chromatin remodeling, HDAC substrates contribute to a deeper understanding of cellular processes such as differentiation, development, and the response to environmental stimuli. Additionally, they are instrumental in the investigation of epigenetic markers and in the identification of novel compounds that modulate HDAC activity, which can be essential for advancing basic biological research and for developing new research tools. View detailed information on our available HDAC substrates by clicking on the product name.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ac-Arg-Gly-Lys(Ac)-MCA

660846-97-9sc-391022
sc-391022A
1 mg
5 mg
$208.00
$832.00
(0)

Ac-Arg-Gly-Lys(Ac)-MCA acts as a histone deacetylase (HDAC) inhibitor through its unique peptide sequence, which facilitates specific binding to the enzyme's active site. The acetylation of the lysine residue enhances its affinity, promoting conformational changes that disrupt HDAC activity. This compound's design allows for precise modulation of protein interactions, influencing gene expression and cellular processes by altering histone acetylation states and chromatin accessibility.