STOP Antibody (A-1): sc-133187

STOP Antibody (A-1) is a mouse monoclonal IgG2b antibody that detects STOP in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STOP, or stable tubule only polypeptide, plays a crucial role in the stabilization of microtubules within the cytoplasm of mammalian cells, particularly under conditions that typically promote depolymerization, such as exposure to cold temperatures or assembly-inhibiting drugs. STOP is essential for maintaining the integrity of the cytoskeleton, as STOP allows certain cell types to possess "cold-stable microtubules" that can withstand extreme conditions, including temperatures as low as -80° C. The structure of STOP includes five tandem repeats of 46 amino acids in its central region, which are vital for its function, as well as a SH3-binding motif near its N-terminus that facilitates interactions with other proteins. The presence of STOP in the cell body and throughout the axon underscores STOP′s importance in neuronal stability and function, making anti-STOP antibody (A-1) an invaluable tool for researchers studying microtubule dynamics and neuronal health.

The preferred STOP antibody is STOP Antibody (H-8): sc-137036.