p63 Antibody (E-9): sc-398800

p63 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects p63 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p63 antibody (E-9) is available in non-conjugated form. p63 (E-9) monoclonal antibody recognizes a crucial transcription factor that plays a significant role in epithelial development and stem cell population maintenance. p63 exists as twelve isoforms, primarily categorized into two main variants: TAp63 and ΔNp63, which arise from alternate promoters and undergo extensive alternative splicing. TAp63, which shares a transactivation domain with p53, is essential for processes such as tubulogenesis and cyst formation, while ΔNp63, known for its oncogenic properties, is vital for cell growth and survival, often acting as a dominant-negative regulator over TAp63 and p53. p63′s ability to modulate these critical cellular functions underscores its importance in both normal development and cancer biology, making anti-p63 antibody (E-9) an invaluable tool for researchers studying these pathways.

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p63 Antibody (E-9) References:

1. p63, cellular senescence and tumor development.  |  Guo, X. and Mills, AA. 2007. Cell Cycle. 6: 305-11. PMID: 17224650
2. p63 in skin appendage development.  |  Mikkola, ML. 2007. Cell Cycle. 6: 285-90. PMID: 17264678
3. p63 in epithelial development.  |  Candi, E., et al. 2008. Cell Mol Life Sci. 65: 3126-33. PMID: 18560758
4. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.  |  Melino, G. 2011. Cell Death Differ. 18: 1487-99. PMID: 21760596
5. p53/p63/p73 in the epidermis in health and disease.  |  Botchkarev, VA. and Flores, ER. 2014. Cold Spring Harb Perspect Med. 4: PMID: 25085956
6. A double dealing tale of p63: an oncogene or a tumor suppressor.  |  Chen, Y., et al. 2018. Cell Mol Life Sci. 75: 965-973. PMID: 28975366
7. Master regulatory role of p63 in epidermal development and disease.  |  Soares, E. and Zhou, H. 2018. Cell Mol Life Sci. 75: 1179-1190. PMID: 29103147
8. Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis.  |  Moses, MA., et al. 2019. Int J Mol Sci. 20: PMID: 31340447
9. Isoform-Specific Roles of Mutant p63 in Human Diseases.  |  Osterburg, C., et al. 2021. Cancers (Basel). 13: PMID: 33572532
10. P63 and P73 Activation in Cancers with p53 Mutation.  |  Cai, BH., et al. 2022. Biomedicines. 10: PMID: 35884795

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p63 Antibody (E-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-p63 Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p63 Antibody (E-9) Specifications

Alternate Product Name: TP63

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 15-151

Epitope Target: ΔN p63α

Epitope Species: human

Product Reactivity/Detection: all p63 isoforms

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for p63 Antibody (E-9): N/A

The preferred p63α antibody is p63α Antibody (C-12): sc-5301.