IL-17 Antibody (G-4): sc-374218

IL-17 Antibody (G-4) is a mouse monoclonal IgG2a kappa light chain antibody specific for an epitope mapping between amino acids 111-140 at the C-terminus of human interleukin-17 (IL-17). IL-17, also known as IL-17A or CTLA-8, is a pro-inflammatory cytokine produced primarily by activated T helper 17 (Th17) cells and plays a pivotal role in immune responses against pathogens. Structurally, IL-17 forms a homodimer consisting of two identical subunits linked by disulfide bonds, a configuration crucial for biological activity and interaction with IL-17 receptor (IL-17R) on target cells. This structural arrangement enables IL-17 to induce the expression of other cytokines and chemokines, amplifying inflammatory responses and contributing to host defense mechanisms. Dysregulation of IL-17 has been implicated in various autoimmune and inflammatory diseases, making IL-17 an important target for therapeutic research. Anti-IL-17 antibody (G-4) reacts with IL-17 from mouse, rat, and human origins and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). By targeting a specific epitope at the C-terminus of IL-17, IL-17 (G-4) antibody facilitates detailed studies on IL-17′s structure-function relationships and role in disease pathogenesis, aiding in the development of strategies to modulate IL-17-mediated inflammatory processes.

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IL-17 Antibody (G-4) References:

1. Microbial lipopeptides induce the production of IL-17 in Th cells.  |  Infante-Duarte, C., et al. 2000. J Immunol. 165: 6107-15. PMID: 11086043
2. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.  |  Yao, Z., et al. 2011. J Immunol. 187: 4392-402. PMID: 22013205
3. IL-17 in human asthma.  |  Silverpil, E. and Lindén, A. 2012. Expert Rev Respir Med. 6: 173-86. PMID: 22455490
4. IL-17 inhibitors in axial spondyloarthritis. An overview.  |  Toussirot, E. and Felten, R. 2024. Expert Opin Biol Ther. 24: 917-932. PMID: 39153184
5. IL-17 family cytokines in inflammatory or autoimmune skin diseases.  |  Kong, B. and Lai, Y. 2024. Adv Immunol. 163: 21-49. PMID: 39271258
6. Cloning of a new cytokine that induces IFN-gamma production by T cells.  |  Okamura, H., et al. 1995. Nature. 378: 88-91. PMID: 7477296
7. Human IL-17: a novel cytokine derived from T cells.  |  Yao, Z., et al. 1995. J Immunol. 155: 5483-6. PMID: 7499828
8. Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.  |  Arend, WP., et al. 1994. J Immunol. 153: 4766-74. PMID: 7963543
9. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.  |  Rouvier, E., et al. 1993. J Immunol. 150: 5445-56. PMID: 8390535
10. Cytokine function: a study in biologic diversity.  |  Cohen, MC. and Cohen, S. 1996. Am J Clin Pathol. 105: 589-98. PMID: 8623768
11. Janus kinases in cytokine signalling.  |  Ihle, JN. 1996. Philos Trans R Soc Lond B Biol Sci. 351: 159-66. PMID: 8650262
12. Complete nucleotide sequence of the mouse CTLA8 gene.  |  Yao, Z., et al. 1996. Gene. 168: 223-5. PMID: 8654948

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-17 Antibody (G-4) has 56 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-17 Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-17 Antibody (G-4) Specifications

Alternate Product Name: Interleukin 17

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 111-140

Epitope Target: IL-17

Epitope Species: human

Product Reactivity/Detection: IL-17

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 56 citations in various scientific publications

Available Conjugates/Forms for IL-17 Antibody (G-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin