HDAC8 Anticuerpo (F-9) es un monoclonal de ratón IgG3 (kappa light chain) proporcionado como 200 µg/ml
específico para un epítopo localizado entre los amino ácidos 2-28 en el N-terminus de HDAC8 de origen human
recomendado para detectarHDAC8 de mouse, rat y human origen, mediante WB, IP, IF y ELISA
Ver HDAC8 (E-5): sc-17778 para HDAC8 anticuerpos conjugados, incluyendo AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 y 790.
Contacte con nosotros para recibir GRATIS 10 µg de muestra de HDAC8 (F-9): sc-374180.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for HDAC8 Antibody (F-9) for WB applications. This reagent is now offered in a bundle with HDAC8 Antibody (F-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
HDAC para análisis funcionales de las repuestas celulares a HDAC
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.