Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CYP27B1 Antibody (G-5) is a high quality monoclonal CYP27B1 antibody (also designated CP27B antibody, Cytochrome P450 Family 27 Subfamily B Member 1 antibody, Calcidiol 1-Monooxygenase antibody, Cytochrome P450 Family 27 Subfamily B Polypeptide 1 antibody, 25-Hydroxyvitamin D-1 Alpha Hydroxylase Mitochondrial antibody, 25-OHD-1 Alpha-Hydroxylase antibody, Cytochrome P450C1 Alpha antibody, Cytochrome P450 27B1 antibody, CYP27B antibody, P450c1 antibody, CYP1ALPHA antibody, CYP27B1 antibody, VDDR I antibody, or VDR antibody) suitable for the detection of the CYP27B1 protein of mouse, rat and human origin. CYP27B1 Antibody (G-5) is available as the non-conjugated anti-CYP27B1 antibody. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP27B1, a 508-amino acid protein that belongs to the XXVIIB subfamily of the cytochrome P450 family, localizes to the mitochondrion and is expressed in the kidney. The CYP27B1 protein catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) and functions in calcium metabolism, normal bone growth, and tissue differentiation. Mutations in the gene which encodes for CYP27B1 cause vitamin D-dependent rickets type 1 (VDDR-1), also designated pseudovitamin D deficiency rickets (PDDR), an autosomal recessive disease characterized by early onset of rickets with hypocalcemia and muscle weakness.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
We are trying to knockdown the CYP28B1 using a sRNA cocktail. We performed the western after treatment with siRNA. Silencing was observed but we are now having one more band just above the CYP27B1 band which is only present in siRNA treated samples.
Preguntado por: Shariq Qayyum
Thank you for your question. Please contact our Technical Service Department for assistance in troubleshooting this antibody.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn