COL5A1 Antibody (E-8): sc-166154

COL5A1 Antibody (E-8) is a mouse monoclonal IgG2b antibody that detects COL5A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COL5A1, a member of the collagen family, plays a crucial role in the formation of type V collagen, which is essential for the structural integrity of various tissues, including skin, tendons, and blood vessels. COL5A1 is primarily located in the extracellular matrix, where COL5A1 contributes to the assembly of collagen fibrils and regulates the diameter of these fibrils, ensuring proper tissue architecture and mechanical properties. COL5A1′s location in the extracellular matrix not only provides tensile strength but also influences cellular behaviors such as migration and differentiation, which are vital for wound healing and tissue repair. COL5A1 interacts with other collagen types and extracellular matrix components, further underscoring COL5A1′s significance in maintaining the overall functionality and stability of connective tissues. With versatile applications and a critical role in connective tissue biology, anti-COL5A1 antibody (E-8) serves as an invaluable tool for researchers studying collagen-related disorders and tissue engineering.

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COL5A1 Antibody (E-8) References:

1. Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin.  |  Zoppi, N., et al. 2004. J Biol Chem. 279: 18157-68. PMID: 14970208
2. Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen-related genes.  |  Fager Ferrari, M., et al. 2021. Haemophilia. 27: e69-e77. PMID: 33161638
3. Identification of Autoimmunity to Peptides of Collagen V α1 Chain as Newly Biomarkers of Early Stage of Systemic Sclerosis.  |  Velosa, APP., et al. 2020. Front Immunol. 11: 604602. PMID: 33643291
4. Overexpressed COL5A1 is correlated with tumor progression, paclitaxel resistance, and tumor-infiltrating immune cells in ovarian cancer.  |  Zhang, J., et al. 2021. J Cell Physiol. 236: 6907-6919. PMID: 33655494
5. COL5A1 Variants Cause Aortic Dissection by Activating TGF-β-Signaling Pathway.  |  Chen, P., et al. 2021. J Am Heart Assoc. 10: e019276. PMID: 34041919
6. COL5A1 Serves as a Biomarker of Tumor Progression and Poor Prognosis and May Be a Potential Therapeutic Target in Gliomas.  |  Gu, S., et al. 2021. Front Oncol. 11: 752694. PMID: 34868960
7. The Hypoxia-Related Gene COL5A1 Is a Prognostic and Immunological Biomarker for Multiple Human Tumors.  |  Zhu, H., et al. 2022. Oxid Med Cell Longev. 2022: 6419695. PMID: 35082969
8. Identification of key genes in colorectal cancer diagnosis by co-expression analysis weighted gene co-expression network analysis.  |  Mortezapour, M., et al. 2023. Comput Biol Med. 157: 106779. PMID: 36931200
9. COL5A1 overexpression correlates with poor prognosis in human cervical cancer.  |  Duan, X., et al. 2024. Int J Biol Markers. 39: 265-273. PMID: 39043220
10. Vascularized characteristics and functional regeneration of three-dimensional cell reconstruction of oral mucosa equivalents based on vascular homeostasis phenotypic modification.  |  Shi, L., et al. 2024. J Tissue Eng. 15: 20417314241268912. PMID: 39301507

The preferred COL5A1 antibody is COL5A1 Antibody (C-5): sc-166155.