ACAP2 Antibody (E-9): sc-271355

ACAP2 Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects ACAP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACAP2, a member of the centaurin GTPase-activating protein family, plays a crucial role in regulating vesicular transport and cytoskeletal organization, which are essential for maintaining cellular integrity and function. ACAP2 is primarily located in peripheral tubular membranes, where ACAP2 interacts with other members of the ARF family, particularly ARF1 and ARF6, to modulate membrane trafficking processes. The interaction of ACAP2 with phosphatidylinositol 4,5-bisphosphate is vital for its GTPase-activating activity, influencing the dynamics of ARF-dependent pathways. Notably, ACAP2′s ability to block ARF6-dependent protrusions upon overexpression highlights its regulatory role in cellular morphology and movement. Additionally, ACAP2 interacts with K1L, a protein necessary for the growth of the Vaccinia Virus, through its ankyrin repeats, underscoring its significance in both cellular and viral processes. ACAP2 (E-9) antibody serves as an invaluable tool for researchers studying these complex interactions and the functional implications of ACAP2 in various biological contexts.

The preferred ACAP2 antibody is ACAP2 Antibody (F-8): sc-376150.