ACAP2 Activators
ACAP2 Activators are chemical compounds that enhance the functional activity of ACAP2, a protein involved in the regulation of intracellular trafficking processes. These activators primarily function by modulating the post-translational modifications of ACAP2 or activating the signaling pathways in which ACAP2 is involved. The chosen ACAP2 Activators include ATP, which enhances ACAP2's GAP activity by providing a higher substrate availability. Forskolin and 8-Bromo-cAMP enhance the activity of ACAP2 by activating protein kinases that can phosphorylate and activate ACAP2. MG-132 is another ACAP2 activator that prevents the degradation of phosphorylated proteins, thereby enhancing the activity of ACAP2.
Other ACAP2 activators, such as PMA, EGF, and Insulin, function by activating protein kinases or signaling pathways that can phosphorylate and activate ACAP2. PD98059, LY294002, Wortmannin, andU0126 are inhibitors that suppress pathways or enzymes that would otherwise inhibit ACAP2, thus indirectly enhancing the activation of ACAP2. BAPTA-AM, a calcium chelator, enhances ACAP2 activity by inhibiting a phosphatase that dephosphorylates ACAP2, thereby maintaining the phosphorylation status and activity of ACAP2. The activation of ACAP2 by these compounds results in the enhancement of its role in intracellular trafficking processes, specifically in the regulation of the ARF6-mediated pathway. These compounds ensure that ACAP2 can effectively regulate the cycle of ARF6 between its inactive GDP-bound state and its active GTP-bound state, thus influencing cellular processes such as endocytosis, exocytosis, and cell migration.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP provides the energy required for ACAP2 to facilitate its GTPase-activating protein (GAP) activity towards ARF6, a small GTPase. An increase in ATP concentration can enhance ACAP2's activity by providing a higher substrate availability. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate ACAP2, which can enhance the activity of ACAP2 by promoting its interaction with ARF6. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, increasing the levels of cyclic AMP (cAMP). Elevated cAMP levels can activate protein kinase A (PKA), which can phosphorylate and activate ACAP2, thus enhancing its GAP activity towards ARF6. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can activate PKA. PKA can phosphorylate and activate ACAP2, thereby enhancing its GAP activity towards ARF6. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of phosphorylated proteins. By preventing the degradation of phosphorylated ACAP2, MG-132 can enhance the activity of ACAP2. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, leading to activation of the PI3K/AKT pathway. ACAP2 is a known downstream effector of this pathway, so activation of this pathway can enhance the activity of ACAP2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK1, which can suppress the activation of ERK1/2. ACAP2 has been shown to be activated by ERK1/2, so inhibition of ERK1/2 activation by PD98059 can enhance the activation of ACAP2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, which can influence the PI3K/AKT pathway. As ACAP2 is a known downstream effector of this pathway, inhibiting PI3K can indirectly enhance the activation of ACAP2. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that can decrease intracellular calcium levels. Reduced calcium levels can inhibit calcineurin, a phosphatase that dephosphorylates ACAP2, thereby maintaining the phosphorylation status and activity of ACAP2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, which can influence the PI3K/AKT pathway. As ACAP2 is a known downstream effector of this pathway, inhibiting PI3K can indirectly enhance the activation of ACAP2. | ||||||