17beta-HSD para análisis funcionales de las repuestas celulares a 17 β-HSD
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17β-HSD4 Antibody (A-6) is a high quality monoclonal 17 beta-HSD4 antibody (also designated 17β-HSD4 antibody) suitable for the detection of the 17 beta-HSD4 protein of human origin. 17β-HSD4 Antibody (A-6) is available as both the non-conjugated anti-17 beta-HSD4 antibody form, as well as multiple conjugated forms of anti-17 beta-HSD4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-β Estradiol dehydrogenase type IV. It belongs to the 17β-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17β-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol β-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17β-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17β-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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