NUDT11 Activators
NUDT11 Activators encompass a range of chemical compounds that directly or indirectly support the activation and functional activity of NUDT11, a protein responsible for hydrolyzing oxidized nucleotides. The activators include substrates such as ADP and oxidized nucleotides, cofactors like magnesium, manganese, and zinc ions, and agents that influence the cellular redox state such as NADH and reduced glutathione. These compounds enhance the functional activity of NUDT11 by either providing substrates for its enzymatic reactions, stabilizing the enzyme structure, or creating favorable conditions for its activity.
For instance, ADP, ATP, and GTP are nucleotides that NUDT11 can process, either directly or after conversion to their diphosphate forms. The presence of these compounds assures a continuous supply of substrates for NUDT11, thereby enhancing its activity. Oxidized nucleotides like 8-oxo-dGTP are directly hydrolyzed by NUDT11, which underscores its role in maintaining the fidelity of the nucleotide pool. On the other hand, metal ions such as magnesium, manganese, and zinc are crucial for the structural and catalytic functionality of NUDT11. These ions enhance the enzyme's activity by acting as cofactors that facilitate the catalytic process.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP is a product of ATP dephosphorylation, and as NUDT11 is implicated in the hydrolysis of oxidized nucleotides, an increase in ADP concentration can enhance NUDT11 activity by providing more substrate for its enzymatic action. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH serves as a reducing agent in various biochemical reactions. An abundance of NADH suggests a high-reducing environment, which may favor the enzymatic activity of NUDT11 as it processes oxidized nucleotides. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Reduced glutathione maintains cellular redox balance. By sustaining a reduced environment, it can promote the function of NUDT11, which may include the reduction of oxidized substrates that NUDT11 acts upon. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can oxidize nucleotides, thus increasing the pool of substrates for NUDT11 and indirectly enhancing its functional activity. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Similar to magnesium, manganese ions can act as cofactors and are known to stabilize the structure of NUDT11, which is necessary for its enzymatic function. | ||||||
Guanosine 5′-Triphosphate, Disodium Salt | 56001-37-7 | sc-295030 sc-295030A | 50 mg 250 mg | $166.00 $327.00 | ||
As a purine nucleotide similar to ATP, GTP can undergo hydrolysis to produce GDP, which may serve as a substrate for NUDT11, thereby promoting its activity. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
Ap4A can be a substrate for NUDT11 and its hydrolysis can enhance NUDT11's activity by providing a feedback mechanism that regulates purine nucleotide levels within the cell. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can influence the structural conformation of NUDT11 and promote its enzymatic activity, as metal ions are often necessary for the catalytic function of enzymes. | ||||||