RyR-1 Antibody (XA7B6): sc-73607

RyR-1 Antibody (XA7B6) is a mouse monoclonal IgM antibody that detects RyR-1 in mouse, rat, rabbit, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. RyR-1, a member of the ryanodine receptor family, plays a crucial role in calcium signaling within muscle cells, specifically in the excitation-contraction coupling process. Located primarily in the sarcoplasmic reticulum of skeletal muscle, RyR-1 is responsible for the release of calcium ions in response to membrane depolarization, which is essential for muscle contraction. The proper functioning of RyR-1 is vital, as any mutations in its gene can lead to severe muscle disorders such as Brody disease, malignant hyperthermia, cardiomyopathy, and central core disease, highlighting its importance in maintaining muscle health and function. RyR-1 (XA7B6) antibody is an invaluable tool for researchers studying these critical pathways and the associated pathologies, providing insights into the molecular mechanisms underlying muscle contraction and related diseases.

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RyR-1 Antibody (XA7B6) References:

1. Isoform-specific interactions between halothane and the ryanodine receptor Ca(2+)-release channel: implications for malignant hyperthermia and the protein theory of anaesthetic action.  |  Frömming, GR. and Ohlendieck, K. 1999. Naturwissenschaften. 86: 584-7. PMID: 10643591
2. Expression of ryanodine receptor type 3 and TRP channels in endothelial cells: comparison of in situ and cultured human endothelial cells.  |  Köhler, R., et al. 2001. Cardiovasc Res. 51: 160-8. PMID: 11399258
3. [mRNA and protein expression of skeletal DHPR(alpha1) and RyRs in diaphragm muscle of rabbits].  |  Zhang, SY., et al. 2000. Sheng Li Xue Bao. 52: 497-501. PMID: 11941415
4. [Effect of chronic electrical stimulation of phrenic nerve at different frequencies on mRNA and protein expression of skeletal DHPR(alpha1) and RyRs in the diaphragm muscle of rabbits].  |  Zhang, SY., et al. 2004. Sheng Li Xue Bao. 56: 198-203. PMID: 15127130
5. Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice.  |  Supnet, C., et al. 2006. J Biol Chem. 281: 38440-7. PMID: 17050533
6. Malignant hyperthermia.  |  Rosenberg, H., et al. 2007. Orphanet J Rare Dis. 2: 21. PMID: 17456235
7. Familial RYR 1 mutation associated with mild and severe central core disease.  |  Erendzhinova, E., et al. 2010. Can J Neurol Sci. 37: 528-31. PMID: 20724266
8. The Arianna thread: the matching of S-100 family with the RyR's muscle receptor.  |  Fulle, S., et al. 2020. Eur J Transl Myol. 30: 8839. PMID: 32499888
9. Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats.  |  Wang, YZ., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118791. PMID: 32619649
10. RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022.  |  O'Connor, TN., et al. 2023. J Neuromuscul Dis. 10: 135-154. PMID: 36404556

The preferred RyR antibody is RyR Antibody (F-1): sc-376507.