ROR1 Antibody (60-D): sc-130386

ROR1 Antibody (60-D) is a mouse monoclonal IgG1 kappa light chain antibody that detects ROR1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ROR1 antibody (60-D) is available as a non-conjugated format. ROR1 plays a crucial role in organogenesis and neuronal differentiation, making ROR1 significant in developmental biology and potential therapeutic applications. Located primarily on the cell surface, ROR1 is involved in various signaling pathways that influence cell growth and differentiation. ROR1 expression is notably increased in certain hematological malignancies, such as acute lymphoblastic leukemia and chronic lymphocytic leukemia, highlighting ROR1 potential as a target for immunotherapy. The ROR family, which includes ROR1 and ROR2, is characterized by unique structural features, including intracellular tyrosine kinase domains and extracellular Frizzled-like cysteine-rich domains, which are essential for cellular signaling. The conservation of ROR1 across species, from C. elegans to mammals, underscores ROR1 fundamental role in biological processes. ROR1 monoclonal antibody (60-D) serves as a valuable tool for researchers investigating ROR1 implications in both normal physiology and disease states.

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ROR1 Antibody (60-D) References:

1. Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans.  |  Yoda, A., et al. 2003. J Recept Signal Transduct Res. 23: 1-15. PMID: 12680586
2. Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons.  |  Paganoni, S. and Ferreira, A. 2003. J Neurosci Res. 73: 429-40. PMID: 12898527
3. A novel family of cell surface receptors with tyrosine kinase-like domain.  |  Masiakowski, P. and Carroll, RD. 1992. J Biol Chem. 267: 26181-90. PMID: 1334494
4. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.  |  Baskar, S., et al. 2008. Clin Cancer Res. 14: 396-404. PMID: 18223214
5. Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia.  |  Shabani, M., et al. 2007. Tumour Biol. 28: 318-26. PMID: 18354269
6. Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy.  |  Daneshmanesh, AH., et al. 2008. Int J Cancer. 123: 1190-5. PMID: 18546292
7. Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia.  |  Shabani, M., et al. 2008. Leuk Lymphoma. 49: 1360-7. PMID: 18604725
8. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling.  |  Winkel, A., et al. 2008. Cell Signal. 20: 2134-44. PMID: 18762249
9. Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies.  |  Zhao, Y., et al. 2021. Front Oncol. 11: 680834. PMID: 34123850
10. The signaling pathways activated by ROR1 in cancer.  |  Quezada, MJ. and Lopez-Bergami, P. 2023. Cell Signal. 104: 110588. PMID: 36621728
11. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.  |  Lin, W., et al. 2023. Nat Commun. 14: 1578. PMID: 36949068
12. ROR1 for Lymphoid Cancers.  |  Schuster, SJ. 2022. NEJM Evid. 1: EVIDe2100014. PMID: 38319244

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ROR1 Antibody (60-D) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ROR1 Antibody (60-D) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ROR1 Antibody (60-D) Specifications

Alternate Product Name: ROR1

Product Clone Name: 60-D

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 294-393

Epitope Target: ROR1

Epitope Species: human

Product Reactivity/Detection: ROR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ROR1 Antibody (60-D): N/A