PTH Antibody (5E745): sc-71944

PTH Antibody (5E745) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human, bovine, and canine samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism by increasing blood calcium levels through multiple mechanisms, such as stimulating bone formation, which enhances bone mass and strength in both rats and humans. Notably, the first 34 amino acids at the amino terminus of the PTH molecule are essential for its biological activity, highlighting the importance of this region in its function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and PTH is intricately linked to parathyroid hormone-related protein (PTH-rP), which, unlike PTH, is produced by various cell types and is involved in regulating endochondral bone development and epithelial-mesenchymal interactions during mammary gland and tooth formation. Both PTH and PTH-rP are influenced by vitamin D and steroid hormones, and these proteins exert their effects by binding to specific PTH/PTH-rP receptors, subsequently activating adenylate cyclase or phospholipase C beta via protein kinase C activation. Anti-PTH antibody (5E745) is an invaluable tool for researchers studying calcium homeostasis and related disorders, providing insights into the physiological and pathological roles of this critical hormone.

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PTH Antibody (5E745) References:

1. Hypercalcemia and breast cancer related to parathormone-like secretion by liver metastases.  |  Bernard, JD., et al. 1992. Gynecol Oncol. 47: 255-9. PMID: 1468705
2. Serum levels of vitamin D, PTH and calcium and breast cancer risk-a prospective nested case-control study.  |  Almquist, M., et al. 2010. Int J Cancer. 127: 2159-68. PMID: 20112341
3. Vitamin D, PTH, and calcium and tumor aggressiveness in prostate cancer: a prospective nested case-control study.  |  Brändstedt, J., et al. 2016. Cancer Causes Control. 27: 69-80. PMID: 26518197
4. Dynamic modeling of bone metastasis, microenvironment and therapy: Integrating parathyroid hormone (PTH) effect, anti-resorptive and anti-cancer therapy.  |  Coelho, RM., et al. 2016. J Theor Biol. 391: 1-12. PMID: 26657065
5. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.  |  Grinman, DY., et al. 2022. Breast Cancer Res. 24: 30. PMID: 35440032
6. Ectopic PTH-producing parathyroid cyst inside the thymus: a case report.  |  Takenouchi, H., et al. 2022. BMC Endocr Disord. 22: 327. PMID: 36544116
7. Effects of Vitamin D3 Supplementation on Cardiovascular and Cancer Outcomes by eGFR in VITAL.  |  Limonte, CP., et al. 2022. Kidney360. 3: 2095-2105. PMID: 36591342
8. Research progress on the pharmacological effects and chemical constituents of Pien Tze Huang and its potential Q-markers.  |  Dong, Z., et al. 2023. Chin J Nat Med. 21: 658-669. PMID: 37777316
9. High Parathyroid Hormone Rather than Low Vitamin D Is Associated with Reduced Event-Free Survival in Childhood Cancer.  |  Grasemann, C., et al. 2024. Cancer Epidemiol Biomarkers Prev. 33: 1414-1422. PMID: 39141058
10. Plasma PTH and PTH-rP levels and clodronate therapy in cancer patients with hypercalcemia.  |  Su, RJ., et al. 1993. J Formos Med Assoc. 92: 977-82. PMID: 7910069

The preferred PTH antibody is PTH Antibody (H-7): sc-398856.