Nodal Antibody (A-9): sc-377508

Nodal Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Nodal in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nodal is a crucial member of the transforming growth factor β (TGFβ) superfamily, playing a significant role in embryonic development and the maintenance of adult tissue homeostasis. anti-Nodal antibody (A-9) is primarily located in the embryonic cells during the early stages of development, particularly in the primitive streak, where Nodal is essential for mesoderm formation. Nodal (A-9) antibody detects this protein at a critical juncture, indicating Nodal′s vital function in orchestrating the differentiation of ectodermal cells into mesoderm, which is foundational for the development of various tissues and organs. Furthermore, Nodal is implicated in the directional processes of heart looping and embryonic turning, highlighting Nodal′s importance in establishing proper embryonic morphology. Nodal monoclonal antibody (A-9) is an invaluable tool for researchers studying developmental biology and the intricate signaling pathways that govern early embryogenesis.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Nodal Antibody (A-9) References:

1. [Nodal paroxysmal tachycardia].  |  Montenero, AS., et al. 1999. Cardiologia. 44 Suppl 1: 449-51. PMID: 12497950
2. Back to the embryonic stage: Nodal as a biomarker for breast cancer progression.  |  Bar-Eli, M. 2012. Breast Cancer Res. 14: 105. PMID: 22643182
3. Nodal promotes glioblastoma cell growth.  |  De Silva, T., et al. 2012. Front Endocrinol (Lausanne). 3: 59. PMID: 22645523
4. Nodal promotes the generation of M2-like macrophages and downregulates the expression of IL-12.  |  Wang, XF., et al. 2014. Eur J Immunol. 44: 173-83. PMID: 24114072
5. Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.  |  Aykul, S., et al. 2015. PLoS One. 10: e0114954. PMID: 25603319
6. Applicability of endoscopic submucosal dissection for undifferentiated early gastric cancer: Mixed histology of poorly differentiated adenocarcinoma and signet ring cell carcinoma is a worse predictive factor of nodal metastasis.  |  Lee, IS., et al. 2017. Surg Oncol. 26: 8-12. PMID: 28317588
7. A contemporary view of atrioventricular nodal physiology.  |  Markowitz, SM. and Lerman, BB. 2018. J Interv Card Electrophysiol. 52: 271-279. PMID: 29909540
8. [Atrioventricular nodal tachycardia].  |  Grolleau, R., et al. 1995. Arch Mal Coeur Vaiss. 88 Spec No 1: 41-51. PMID: 7786144
9. The impact of patterns of nodal metastasis on modifications of neck dissection.  |  Shah, JP. and Andersen, PE. 1994. Ann Surg Oncol. 1: 521-32. PMID: 7850559
10. AV nodal reentrant tachycardia with unusual characteristics: lessons from radiofrequency catheter ablation.  |  Chen, SA., et al. 1998. J Cardiovasc Electrophysiol. 9: 321-33. PMID: 9554737

The preferred Nodal antibody is Nodal Antibody (WS65): sc-81953.