IL-10 Antibody (2G101H7): sc-57245
- IL-10 Antibody (2G101H7) is a mouse monoclonal IgG1, cited in 10 publications, provided at 100 µg/ml
- raised against full length IL-10 of rat origin
- recommended for detection of recombinant and native IL-10 of mouse and rat origin by WB, FCM and ELISA
- See IL-10 (A-2): sc-365858 for IL-10 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-10 Antibody (2G101H7). This work is in progress.
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IL-10 Antibody (2G101H7) is a mouse monoclonal IgG1 antibody that detects interleukin-10 in mouse and rat samples through applications such as western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IL-10 is a crucial cytokine primarily secreted by TH2 clones, playing a significant role in immune regulation by suppressing cytokine production from TH1 clones in response to antigens presented by monocyte and macrophage antigen presenting cells. This suppression is vital for maintaining immune homeostasis and preventing excessive inflammatory responses, which can lead to tissue damage. Additionally, IL-10 inhibits the activation of cytokine-targeted cells, potentially through the downregulation of CD25, the IL-2 receptor, on macrophages and B lymphocytes. Notably, human and murine IL-10 share a high degree of sequence identity, with 81% similarity at the amino acid level, indicating conserved functions across species. The biological activity of IL-10 is mediated through IL-10R, a glycoprotein that can be induced in cultured macrophages and fibroblasts by lipopolysaccharide stimulation. Elevated levels of IL-10 have been observed in individuals infected with HIV-1, suggesting involvement in disease progression, making anti-IL-10 antibody (2G101H7) an essential tool for researchers studying immune responses and related pathologies.
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IL-10 Antibody (2G101H7) References:
- Interleukin-10 in the brain. | Strle, K., et al. 2001. Crit Rev Immunol. 21: 427-49. PMID: 11942558
- The role of IL-10 in regulating immunity to persistent viral infections. | Wilson, EB. and Brooks, DG. 2011. Curr Top Microbiol Immunol. 350: 39-65. PMID: 20703965
- Structural analysis of cytokines comprising the IL-10 family. | Zdanov, A. 2010. Cytokine Growth Factor Rev. 21: 325-30. PMID: 20846897
- Significant roles played by IL-10 in Chlamydia infections. | Hakimi, H., et al. 2014. Inflammation. 37: 818-23. PMID: 24398613
- Regulation of Interleukin-10 Expression. | Rutz, S. and Ouyang, W. 2016. Adv Exp Med Biol. 941: 89-116. PMID: 27734410
- Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β. | Abdoli, A., et al. 2017. Comp Immunol Microbiol Infect Dis. 51: 15-26. PMID: 28504090
- IL-10 enhances T cell survival and is associated with faster relapse in patients with inactive ulcerative colitis. | Wang, S., et al. 2020. Mol Immunol. 121: 92-98. PMID: 32193038
- Enhanced IL-10 inhibits proliferation and promotes apoptosis of HUVECs through STAT3 signaling pathway in sepsis. | Xie, Z., et al. 2021. Histol Histopathol. 36: 1179-1187. PMID: 34528700
- CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. | Yogev, N., et al. 2022. Cell Rep. 38: 110565. PMID: 35354043
- Single-cell RNA sequencing analysis reveals the heterogeneity of IL-10 producing regulatory B cells in lupus-prone mice. | Daamen, AR., et al. 2023. Front Immunol. 14: 1282770. PMID: 38155972
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-10 Antibody (2G101H7) | sc-57245 | 100 µg/ml | $322.00 |