Ig lambda chain Antibody (Rs4): sc-51638
- Ig λ chain Antibody (Rs4) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against λ light chains of human IgG
- recommended for detection of λ light chains of Ig of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ig λ chain Antibody (Rs4). This work is in progress.
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Ig λ chain Antibody (Rs4) is a mouse monoclonal IgG1 light chain antibody that detects Ig λ chain in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Ig λ chain plays a crucial role in the immune response by forming part of the immunoglobulin structure, which is essential for recognizing and binding to antigens. Anti-Ig λ chain antibody (Rs4) targets proteins primarily located in the cytoplasm of B cells, where Ig λ chain associates with heavy chains to form functional antibodies. The presence of Ig λ chain is particularly important because this protein allows for the generation of diverse antibody specificities, enabling the immune system to effectively target a wide range of pathogens. Additionally, Ig λ chain expression can influence the overall antibody response, as different light chain isotypes can affect the stability and functionality of the resulting immunoglobulin. Ig λ chain monoclonal antibody (Rs4) serves as an invaluable tool for researchers studying B cell development and the mechanisms of antibody diversity, providing insights into the adaptive immune system′s ability to respond to various challenges.
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Ig lambda chain Antibody (Rs4) References:
- Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments. | Boursier, L., et al. 2003. Mol Immunol. 39: 1025-34. PMID: 12749909
- Antibodies directed against a yeast carboxyl-terminal peroxisomal targeting signal specifically recognize peroxisomal proteins from various yeasts. | Aitchison, JD., et al. 1992. Yeast. 8: 721-34. PMID: 1279909
- Proteomics comparison of the sera from multiple sclerosis patients and neuromyelitis optica patients. | Jiang, SF., et al. 2014. Genet Mol Res. 13: 9292-9. PMID: 24615106
- Molecular cloning of a bovine immunoglobulin lambda chain cDNA. | Ivanov, VN., et al. 1988. Gene. 67: 41-8. PMID: 2843438
- Metallomics-based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients. | de Souza Pessôa, G., et al. 2020. Rapid Commun Mass Spectrom. 34 Suppl 3: e8698. PMID: 31837042
- Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins. | Jung, YM., et al. 2022. Reprod Sci. 29: 1756-1763. PMID: 35165813
- Sensitization to avian and fungal proteins in different work environments. | Sánchez-Díez, S., et al. 2023. Allergy Asthma Clin Immunol. 19: 96. PMID: 37957771
- Complement C3 is downregulated following ranibizumab intervention in experimental central retinal vein occlusion. | Cehofski, LJ., et al. 2024. Mol Vis. 30: 268-277. PMID: 39563678
- Multiple expression of Ig lambda-chain encoding RNA species in murine plasmacytoma cells. | Schwartz, RC., et al. 1981. J Immunol. 126: 2104-8. PMID: 6164720
- The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. | Guelpa-Fonlupt, V., et al. 1994. Mol Immunol. 31: 1099-108. PMID: 7935499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ig λ chain Antibody (Rs4) | sc-51638 | 100 µg/ml | $322.00 |