IFN-γ/Interferon gamma Antibody (H3-1): sc-51975
- IFN-γ/Interferon gamma Antibody (H3-1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against human recombinant interferon γ
- recommended for detection of IFNγ of human origin by WB and IP
- See IFN-γ/Interferon gamma (E-10): sc-373727 for IFN-γ/Interferon gamma antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (H3-1). This work is in progress.
IFN-γ Antibody (H3-1) is a mouse monoclonal IgG1 antibody that detects Interferon (IFN)-γ in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Anti-IFN-γ antibody (H3-1) recognizes a protein that modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functionality is further enhanced by the presence of multiple forms resulting from variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions. The versatility of IFN-γ in immune modulation underscores its significance in therapeutic applications and research, making IFN-γ monoclonal antibody (H3-1) an essential tool for studying immune responses in human samples.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-γ/Interferon gamma Antibody (H3-1) References:
- IFN-gamma therapy of tuberculosis and related infections. | Reljic, R. 2007. J Interferon Cytokine Res. 27: 353-64. PMID: 17523867
- Metabolic Signaling Drives IFN-γ. | Siska, PJ. and Rathmell, JC. 2016. Cell Metab. 24: 651-652. PMID: 27829134
- IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. | Aqbi, HF., et al. 2018. J Leukoc Biol.. PMID: 29469956
- IFN-γ + 874T/A polymorphism and osteomyelitis. | Joob, B. and Wiwanitkit, V. 2020. Int J Immunogenet. 47: 189. PMID: 31840429
- Changing the paradigm of IFN-γ at the interface between innate and adaptive immunity: Macrophage-derived IFN-γ. | Mezouar, S. and Mege, JL. 2020. J Leukoc Biol. 108: 419-426. PMID: 32531848
- IFN-γ mediates Paneth cell death via suppression of mTOR. | Araujo, A., et al. 2021. Elife. 10: PMID: 34633285
- ILC1-derived IFN-γ regulates macrophage activation in colon cancer. | Zhang, Y., et al. 2023. Biol Direct. 18: 56. PMID: 37679802
- IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM. | Liang, T., et al. 2023. J Mol Neurosci. 73: 946-955. PMID: 37889394
- IFN-γ and YAP lead epithelial cells astray after severe respiratory infection. | Hiller, BE. and Mizgerd, JP. 2024. J Clin Invest. 134: PMID: 39352386
- The glycosylation heterogeneity of recombinant human IFN-gamma. | Hooker, A. and James, D. 1998. J Interferon Cytokine Res. 18: 287-95. PMID: 9620355
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (H3-1) | sc-51975 | 100 µg/ml | $322.00 |