IDO Antibody (E-11): sc-365517
- IDO Antibody (E-11) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-35 near the N-terminus of IDO of mouse origin
- recommended for detection of IDO of mouse, rat and human origin by WB, IP, IF and ELISA
- See IDO (mIDO-48): sc-53978 for IDO antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IDO Antibody (E-11). This work is in progress.
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IDO Antibody (E-11) is a mouse monoclonal IgM antibody that detects indoleamine 2,3-dioxygenase (IDO) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IDO is a crucial enzyme that catalyzes the degradation of the essential amino acid L-tryptophan into N-formylkynurenine, playing a significant role in immune regulation and tolerance. This enzymatic activity helps modulate immunological responses, protecting allogeneic concepti from alloreactive maternal lymphocytes, which is vital during pregnancy. IDO can inhibit T cell proliferation, as demonstrated in studies where IDO-transfected cells co-cultured with T cells resulted in reduced T cell activity. Additionally, IDO interaction with CD123-positive dendritic cells highlights its role in suppressing T cell responses, making IDO a potential target for therapeutic strategies aimed at modulating immune responses. Pharmacological or genetic manipulation of IDO may provide valuable insights into controlling undesirable T cell activity, offering new avenues for treatment in various immunological disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IDO Antibody (E-11) | sc-365517 | 200 µg/ml | $322.00 | |||
IDO (E-11) Neutralizing Peptide | sc-365517 P | 100 µg/0.5 ml | $69.00 |