Fatso Antibody (E-10): sc-515411

Fatso Antibody (E-10) is a mouse monoclonal IgG2b antibody that detects Fatso in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fatso, also known as FTO or KIAA1752, is a 505 amino acid protein characterized by an N-terminal nuclear localization signal, which directs Fatso to the nucleus where Fatso plays a significant role in regulating energy homeostasis and fat metabolism. Fatso expression is notably high in brain and pancreatic tissues, and Fatso exists in four alternatively spliced isoforms, one of which has been linked to a predisposition for obesity in both children and adults. This connection to obesity suggests that Fatso may influence body mass index and contribute to the pathogenesis of type 2 diabetes, a major health concern worldwide. The gene encoding Fatso is located on human chromosome 16, a region that harbors over 900 genes and is implicated in various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome. Anti-Fatso antibody (E-10) is an essential tool for researchers investigating the molecular mechanisms underlying obesity and metabolic disorders, providing insights into potential therapeutic targets.

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Fatso Antibody (E-10) References:

1. The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.  |  Ruud, J., et al. 2019. Cell Rep. 27: 3182-3198.e9. PMID: 31189104
2. Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin.  |  Wang, Y., et al. 2021. Bioengineered. 12: 1874-1889. PMID: 34076564
3. FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons.  |  Fu, G., et al. 2021. Stroke. 52: 2393-2403. PMID: 34102854
4. Intrathecal administration of the fat-mass and obesity-associated protein inhibitor mitigates neuropathic pain in female rats.  |  Li, X. and Tao, YX. 2022. Transl Perioper Pain Med. 9: 478-487. PMID: 36545239
5. Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model.  |  Phan, T., et al. 2023. Front Oncol. 13: 1087644. PMID: 36874096
6. Fat mass and obesity-associated protein inhibit the pathology of rheumatoid arthritis through the NSUN2/SFRP1/Wnt/β-catenin signal axis.  |  Huang, Y., et al. 2024. J Pharm Pharmacol. 76: 283-294. PMID: 38243394
7. Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.  |  Ji, W., et al. 2024. Int Immunopharmacol. 132: 111968. PMID: 38579565
8. Fat mass and obesity-associated protein regulates RNA methylation associated with spatial cognitive dysfunction after chronic cerebral hypoperfusion.  |  Wang, Y., et al. 2024. Neuropeptides. 105: 102428. PMID: 38583362
9. Fat Mass and Obesity-Associated Protein Regulates Granulosa Cell Aging by Targeting Matrix Metalloproteinase-2 Gene Via an N6-Methyladenosine-YT521-B Homology Domain Family Member 2-Dependent Pathway in Aged Mice.  |  Li, L., et al. 2024. Reprod Sci. 31: 3498-3511. PMID: 38995602
10. Fat Mass- and Obesity-Associated Protein (FTO) Promotes the Proliferation of Goat Skeletal Muscle Satellite Cells by Stabilizing DAG1 mRNA in an IGF2BP1-Related m6A Manner.  |  Yao, J., et al. 2024. Int J Mol Sci. 25: PMID: 39337293

The preferred Fatso antibody is Fatso Antibody (C-3): sc-271713.