Collagen I, human: sc-136154
- 10 mg
- from human placenta; type 1 (source material tested for hepatitis B antigen, HIV-1 antibody and HIV-2 antibody)
- found in most tissues and organs, plentiful in the dermis, tendon and bone; generally used as a thin layer on tissue-culture surfaces to enhance cell attachment and proliferation, but may be used as a gel if desired
- tested and found negative for the presence of bacteria, fungi and mycoplasma
- purity ≥ 90%
- Store at -20° C
Collagen I, a major structural protein found in various connective tissues, is widely used in scientific research, particularly in the fields of cell biology, tissue engineering, and biomaterials. As the most abundant collagen type in mammals, it forms strong, insoluble fibers that provide structural support and tensile strength to tissues such as skin, bone, tendon, and ligaments. In research, Collagen I is frequently employed as a substrate or scaffold in cell culture systems. It provides a biomimetic surface that promotes cell attachment, proliferation, and differentiation, particularly for cells that are part of the connective tissue lineage. This is because Collagen I interacts with specific cell surface receptors called integrins, which mediate cellular adhesion and initiate intracellular signaling pathways that regulate cell morphology, migration, and the cell cycle. Furthermore, Collagen I is instrumental in the study of wound healing and tissue regeneration. It serves as a scaffold in tissue engineering applications, supporting the growth of new tissues. Researchers utilize Collagen I to fabricate three-dimensional biocompatible scaffolds that mimic the natural extracellular matrix, enhancing the integration and functionality of engineered tissues.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Collagen I, human | sc-136154 | 10 mg | $312.00 |