COL2A1 Antibody (1H1): sc-517571
- COL2A1 Antibody (1H1) is a mouse monoclonal IgG, cited in 1 publications, provided at 100 µg/ml
- raised against Collagen α1 Type II of human origin
- recommended for detection of Collagen α1 Type II of mouse, rat and human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL2A1 Antibody (1H1). This work is in progress.
COL2A1 Antibody (1H1) is a mouse monoclonal IgG antibody that detects Collagen Type II in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Collagen Type II antibody (1H1) plays a crucial role in the study of connective tissues, particularly in cartilage, where Collagen Type II is the predominant fibril-forming protein. Collagen Type II is essential for maintaining the structural integrity and mechanical properties of cartilage, which is vital for joint function and mobility. The unique triple helix structure of Collagen Type II allows for tensile strength and resilience, enabling cartilage to withstand compressive forces experienced in joints. Additionally, alterations in Collagen Type II can lead to various pathologies, including osteoarthritis and other degenerative joint diseases, making Collagen Type II a significant target for research and therapeutic interventions. Anti-Collagen Type II antibody (1H1) effectively labels Collagen Type II in tissue samples, enhancing research capabilities for understanding this protein′s role in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COL2A1 Antibody (1H1) References:
- Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice. | Sakai, K., et al. 2001. Matrix Biol. 19: 761-7. PMID: 11223335
- A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice. | Sahlman, J., et al. 2004. Arthritis Rheum. 50: 3153-60. PMID: 15476249
- Nkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcription. | Kawato, Y., et al. 2012. PLoS One. 7: e34703. PMID: 22511961
- ROCK inhibition stimulates SOX9/Smad3-dependent COL2A1 expression in inner meniscus cells. | Furumatsu, T., et al. 2016. J Orthop Sci. 21: 524-529. PMID: 27113646
- Deep Intronic Sequence Variants in COL2A1 Affect the Alternative Splicing Efficiency of Exon 2, and May Confer a Risk for Rhegmatogenous Retinal Detachment. | Spickett, C., et al. 2016. Hum Mutat. 37: 1085-96. PMID: 27406592
- [Identification of a novel COL2A1 variant in a pedigree affected with spondyloepiphyseal dysplasia congenita]. | Wang, Y., et al. 2019. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 36: 694-696. PMID: 31302913
- miR-455-3p enhances chondrocytes apoptosis and inflammation by targeting COL2A1 in the in vitro osteoarthritis model. | Cheng, F., et al. 2020. Biosci Biotechnol Biochem. 84: 695-702. PMID: 31809639
- CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A. | Kung, LHW., et al. 2020. Stem Cell Res. 48: 101962. PMID: 33002832
- A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes. | Ball, HC., et al. 2021. Connect Tissue Res. 62: 615-628. PMID: 33043724
- Long non-coding RNA RP11-81H3.2 suppresses apoptosis by targeting microRNA-1539/COL2A1 in human nucleus pulposus cells. | Qiao, L., et al. 2021. Exp Ther Med. 22: 884. PMID: 34194562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL2A1 Antibody (1H1) | sc-517571 | 100 µg/ml | $322.00 |