caspase-9 Antibody (4E31): sc-70506

Caspase-9 Antibody (4E31) is a mouse monoclonal IgG1 antibody that detects caspase-9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-caspase-9 antibody (4E31) enables researchers to study a protein that plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase activated in response to cellular stress and mitochondrial dysfunction. Upon activation, caspase-9 cleaves and activates downstream effector caspases, such as caspase-3 and caspase-7, leading to the execution phase of apoptosis. This process is crucial for maintaining cellular homeostasis and eliminating damaged or unwanted cells, thereby preventing the development of various diseases, including cancer. Caspase-9 activation is tightly regulated and can be influenced by various post-translational modifications, such as phosphorylation and ubiquitination, which can affect activity and stability. Understanding caspase-9 function and regulation is essential for elucidating apoptosis mechanisms and developing therapeutic strategies for diseases characterized by dysregulated cell death. Caspase-9 monoclonal antibody (4E31) serves as an invaluable tool for researchers studying apoptosis and its implications in health and disease.

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caspase-9 Antibody (4E31) References:

1. Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.  |  Yin, Q., et al. 2006. Mol Cell. 22: 259-68. PMID: 16630893
2. Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei.  |  Taranukhin, AG., et al. 2008. Amino Acids. 34: 169-74. PMID: 17297564
3. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members.  |  Chen, M., et al. 2007. J Biol Chem. 282: 33888-33895. PMID: 17893147
4. Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.  |  Yoo, NJ., et al. 2010. Tumori. 96: 138-42. PMID: 20437871
5. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.  |  Akpan, N., et al. 2011. J Neurosci. 31: 8894-904. PMID: 21677173
6. A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation.  |  Clemente, N., et al. 2015. Genes Immun. 16: 151-61. PMID: 25569260
7. Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.  |  Guo, R., et al. 2016. Sci Rep. 6: 32447. PMID: 27580936
8. Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells.  |  Liao, G., et al. 2022. Am J Respir Cell Mol Biol. 66: 223-234. PMID: 34705620
9. Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification.  |  Porubský, M., et al. 2022. Bioorg Chem. 129: 106151. PMID: 36220004
10. Nitric oxide and thioredoxin modulate the activity of caspase 9 in HepG2 cells.  |  Chakraborty, S., et al. 2023. Biochim Biophys Acta Gen Subj. 1867: 130452. PMID: 37652366

The preferred caspase-9 antibody is caspase-9 Antibody (96.1.23): sc-56076.