ASK 1 Antibody (E-6): sc-390397
- ASK 1 Antibody (E-6) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of ASK 1 of human origin
- recommended for detection of ASK 1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See ASK 1 (F-9): sc-5294 for ASK 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ASK 1 Antibody (E-6) for WB applications. This reagent is now offered in a bundle with ASK 1 Antibody (E-6) (see ordering information below).
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ASK 1 Antibody (E-6) is a mouse monoclonal IgG2a antibody that detects ASK1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASK1, or Apoptosis Signal-regulating Kinase 1, plays a crucial role in cellular stress responses, particularly in the activation of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways, which are essential for regulating apoptosis and inflammation. ASK1 mediates cellular responses to various stressors, including oxidative stress and pro-inflammatory cytokines, thereby influencing cell survival and death. Dysregulation of ASK1 has been implicated in several diseases, including cancer and neurodegenerative disorders, making ASK1 a significant target for therapeutic intervention. Anti-ASK1 antibody (E-6) provides a reliable tool for researchers aiming to study the functional dynamics of ASK1 in various biological contexts, facilitating a deeper understanding of ASK1′s role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ASK 1 Antibody (E-6) References:
- [Functional analysis of apoptosis signal-regulating kinase 1 (ASK 1)-binding proteins]. | Mochida, Y. 2000. Kokubyo Gakkai Zasshi. 67: 182-92. PMID: 10921242
- Combined use of the ASK and SHK-1 cell lines to enhance the detection of infectious salmon anemia virus. | Rolland, JB., et al. 2005. J Vet Diagn Invest. 17: 151-7. PMID: 15825496
- Dechloromonas hortensis sp. nov. and strain ASK-1, two novel (per)chlorate-reducing bacteria, and taxonomic description of strain GR-1. | Wolterink, A., et al. 2005. Int J Syst Evol Microbiol. 55: 2063-2068. PMID: 16166710
- Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. | Ebrahimian, T., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H1481-8. PMID: 18676690
- Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury. | Wu, D. and Cederbaum, A. 2010. Free Radic Biol Med. 49: 348-60. PMID: 20438834
- Ginsenoside F(2) induces apoptosis in humor gastric carcinoma cells through reactive oxygen species-mitochondria pathway and modulation of ASK-1/JNK signaling cascade in vitro and in vivo. | Mao, Q., et al. 2014. Phytomedicine. 21: 515-22. PMID: 24252332
- Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis. | Kojima, K., et al. 2021. J Biochem. 169: 395-407. PMID: 33377973
- MicroRNA-494 represses osteosarcoma development by modulating ASK-1 related apoptosis complexes. | Gao, G. and Jian, Y. 2020. Transl Cancer Res. 9: 4121-4130. PMID: 35117781
- TRAIL predisposes non-small cell lung cancer to ferroptosis by regulating ASK-1/JNK1 pathway. | Liu, X., et al. 2024. Discov Oncol. 15: 45. PMID: 38383815
- Down-regulation of PGAM5 attenuates spinal cord injury-induced neuronal injury by inhibiting ASK-1/p38/NF-kB signaling. | Guan, J., et al. 2024. Folia Neuropathol.. PMID: 39165217
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASK 1 Antibody (E-6) | sc-390397 | 200 µg/ml | $322.00 | |||
ASK 1 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-540798 | 200 µg Ab; 10 µg BP | $361.00 | |||
ASK 1 (E-6) Neutralizing Peptide | sc-390397 P | 100 µg/0.5 ml | $69.00 |