Date published: 2026-4-24

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ASK 1 Inhibitors

ASK 1 inhibitors are a group of chemical compounds designed to target and inhibit the activity of the Apoptosis Signal-regulating Kinase 1 (ASK 1). ASK 1 is a key component of cellular stress response pathways and serves as a vital regulator of apoptosis and inflammation. When cells encounter various stressors, such as reactive oxygen species, misfolded proteins, or pro-inflammatory cytokines, ASK 1 becomes activated, initiating a cascade of signaling events that ultimately lead to programmed cell death or inflammatory responses. ASK1 inhibitors act by binding to ASK 1 and interfering with its enzymatic function. By doing so, they effectively block the downstream signaling processes, preventing the activation of apoptotic pathways and reducing pro-inflammatory cytokine production. This molecular intervention holds great promise for exploring new avenues in cellular signaling research and unveiling critical connections between stress response mechanisms and disease development. Scientists and researchers are actively investigating ASK 1 and its inhibitors to gain a deeper understanding of how these molecules influence cell behavior under various stress conditions. The exploration of ASK 1 inhibitors has expanded beyond basic research and has implications in various disease contexts. The study of ASK 1 inhibitors represents a fascinating area of research, holding the promise of unveiling new insights into cellular processes and possibly leading to the development of innovative approaches for future biomedical investigations.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4-Methyl-3-(trifluoromethyl)benzoic acid

261952-01-6sc-262082
sc-262082A
5 g
25 g
$90.00
$334.00
(0)

Small molecule ASK1 inhibitor with a specific mechanism of action. M2708 inhibits ASK1 activity and the downstream JNK and p38 MAPK pathways. This compound has potential therapeutic applications in inflammatory diseases and cancer.

Ulixertinib

869886-67-9sc-507296
10 mg
$176.00
(0)

Potent and selective ASK1 inhibitor. Ulixertinib targets ASK1 and inhibits its activity, leading to the suppression of JNK and p38 MAPK signaling pathways. By blocking ASK1, Ulixertinib reduces apoptosis and inflammation. The compound is being studied for its potential therapeutic applications in cancer and inflammatory diseases.

GSK461364

929095-18-1sc-364504
sc-364504A
10 mg
50 mg
$500.00
$1540.00
(0)

Small molecule inhibitor that specifically targets ASK1. GSK 461364 inhibits ASK1 activity, leading to the suppression of the JNK and p38 MAPK pathways. By blocking ASK1, this compound reduces apoptosis and inflammation. GSK 461364 has potential therapeutic implications in various diseases, particularly in the context of neurodegenerative disorders and inflammatory conditions.

D-JNKI-1

1445179-97-4sc-507347
10 mg
$620.00
(0)

Small molecule inhibitor that targets ASK1. JNKi-1 inhibits ASK1 activity, leading to the suppression of the JNK and p38 MAPK pathways. By blocking ASK1, JNKi-1 reduces apoptosis and inflammation. This compound has potential therapeutic implications in cancer and inflammatory diseases.

LY2228820

862507-23-1sc-364525
5 mg
$191.00
1
(0)

Potent and selective ASK1 inhibitor. Ralimetinib targets ASK1 and inhibits its activity, leading to the suppression of JNK and p38 MAPK signaling pathways. By blocking ASK1, Ralimetinib reduces apoptosis and inflammation. The compound is being studied for its potential therapeutic applications in cancer and inflammatory diseases.

BMS 582949

623152-17-0sc-507348
5 mg
$510.00
(0)

Small molecule ASK1 inhibitor with a specific mechanism of action. BMS 582949 inhibits ASK1 activity and the downstream JNK and p38 MAPK pathways. This compound has potential therapeutic applications in inflammatory diseases and cancer.

MEK 162

606143-89-9sc-488879
10 mg
$306.00
(0)

Potent and selective ASK1 inhibitor. Binimetinib targets ASK1 and inhibits its activity, leading to the suppression of JNK and p38 MAPK signaling pathways. By blocking ASK1, Binimetinib reduces apoptosis and inflammation. The compound is being studied for its potential therapeutic applications in cancer and inflammatory diseases.

TAK 715

303162-79-0sc-362799
sc-362799A
10 mg
50 mg
$185.00
$781.00
(0)

Inhibits ASK1 through a specific mechanism. TAK-715 targets ASK1 and inhibits its activity, leading to the suppression of JNK and p38 MAPK pathways. By blocking ASK1, TAK-715 reduces apoptosis and inflammation. The compound has potential therapeutic applications in various inflammatory and immune-related disorders.