SLM-1 Activators
SLM-1, also known as Serum-Response Factor (SRF)-like protein MIBP, represents a crucial transcription factor orchestrating a myriad of cellular processes essential for growth, development, and tissue homeostasis. As a member of the MADS-box transcription factor family, SLM-1 plays a pivotal role in regulating gene expression by binding to specific DNA sequences called serum response elements (SREs) within the promoter regions of its target genes. Through this interaction, SLM-1 modulates the transcriptional activity of genes involved in various cellular functions, including cell proliferation, differentiation, and cytoskeletal organization. The diverse array of genes under the transcriptional control of SLM-1 underscores its significance in governing fundamental cellular processes essential for organismal development and tissue integrity.
Activation of SLM-1 involves intricate signaling cascades initiated by extracellular stimuli that converge on distinct intracellular pathways regulating its activity. Various signaling molecules, such as neurotransmitters, hormones, and growth factors, exert their influence on SLM-1 through specific receptors present on the cell surface. Upon receptor activation, intracellular signaling pathways are triggered, leading to the activation of downstream kinases and transcriptional regulators. These pathways encompass well-characterized mechanisms involving cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), protein kinase C (PKC), and other signaling molecules, culminating in the phosphorylation and activation of SLM-1. Additionally, alternative pathways may involve the modulation of cellular metabolic processes or cytoskeletal dynamics, indirectly influencing SLM-1 activity through complex cellular networks. The activation of SLM-1 by diverse signaling pathways underscores its versatility and adaptability in responding to various extracellular cues to regulate gene expression and cellular function in a context-dependent manner.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates SLM-1 through the adenylate cyclase pathway, leading to increased intracellular levels of cAMP. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates SLM-1 by binding to β-adrenergic receptors on the cell surface, leading to the activation of adenylate cyclase and subsequent production of cAMP. Elevated cAMP levels activate PKA, which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates SLM-1 through the protein kinase C (PKC) pathway, leading to the phosphorylation and activation of SLM-1. PKC activation by PMA initiates downstream signaling events that ultimately enhance the functional activity of SLM-1. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine activates SLM-1 by binding to histamine receptors on the cell surface, leading to the activation of phospholipase C (PLC). PLC activation results in the generation of inositol trisphosphate (IP3) and diacylglycerol (DAG), which activate protein kinase C (PKC) and subsequently phosphorylate and activate SLM-1, enhancing its functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates SLM-1 by binding to β-adrenergic receptors on the cell surface, leading to the activation of adenylate cyclase and subsequent production of cAMP. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
PGE1 activates SLM-1 through the prostaglandin E receptor, leading to the activation of adenylate cyclase and subsequent production of cAMP. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
This compound activates SLM-1 by binding to serotonin receptors on the cell surface, leading to the activation of adenylate cyclase and subsequent production of cAMP. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates SLM-1 by binding to dopamine receptors on the cell surface, leading to the activation of adenylate cyclase and subsequent production of cAMP. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates SLM-1, thereby enhancing its functional activity. | ||||||
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $64.00 $136.00 $459.00 $765.00 | 2 | |
GABA activates SLM-1 by binding to GABA receptors on the cell surface, leading to the inhibition of adenylate cyclase activity and subsequent reduction in cAMP levels. Decreased cAMP levels alleviate PKA-mediated inhibition of SLM-1, thereby enhancing its functional activity. | ||||||