GABAA R α 3 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CL 218872 | 66548-69-4 | sc-203552 sc-203552A | 10 mg 50 mg | $85.00 $319.00 | ||
CL 218872 is a selective modulator of the GABA_A receptor, specifically engaging the alpha-3 subunit. Its binding profile is characterized by a combination of ionic and hydrophobic interactions, which stabilize the receptor in an active conformation. This compound exhibits a rapid onset of action, facilitating immediate receptor activation. Furthermore, its unique structural features allow for distinct conformational changes, influencing downstream signaling pathways and enhancing synaptic efficacy. | ||||||
TB 21007 | 207306-50-1 | sc-204322 sc-204322A | 10 mg 50 mg | $172.00 $729.00 | ||
TB 21007 is a selective GABA_A receptor modulator that targets the alpha-3 subunit, exhibiting a unique binding affinity that promotes receptor desensitization. Its molecular interactions involve a delicate balance of hydrogen bonding and van der Waals forces, leading to altered receptor dynamics. The compound's kinetic profile reveals a slow dissociation rate, prolonging its effects on neurotransmission. Additionally, TB 21007's structural characteristics enable it to influence allosteric sites, modulating receptor activity with precision. | ||||||
L-838417 | 286456-42-6 | sc-211693 sc-211693A sc-211693B sc-211693C sc-211693D | 5 mg 10 mg 100 mg 500 mg 1 g | $249.00 $430.00 $3000.00 $13500.00 $19500.00 | ||
L-838417 is a selective modulator of the GABA_A receptor, specifically engaging the alpha-3 subunit. Its unique interaction profile includes a high degree of specificity, allowing for targeted receptor activation while minimizing off-target effects. The compound exhibits a distinctive mechanism of action, characterized by rapid onset and sustained receptor engagement. Its structural features facilitate unique conformational changes in the receptor, enhancing synaptic inhibition and influencing downstream signaling pathways. | ||||||
THIP hydrochloride | 64603-91-4 | sc-204342 | 50 mg | $155.00 | 2 | |
THIP hydrochloride is a selective GABAA receptor agonist that targets receptors containing δ subunits, often in conjunction with α subunits, including Rα3. By directly activating these GABAA receptors, Gaboxadol enhances chloride ion flow and inhibitory neurotransmission. | ||||||
Isoflurane | 26675-46-7 | sc-470926 sc-470926A | 5 g 25 g | $69.00 $219.00 | 7 | |
Isoflurane, an inhalational anesthetic, enhances GABAA receptor-mediated inhibitory neurotransmission. It acts as a positive allosteric modulator of the receptor, potentially affecting receptors with the Rα3 subunit, and increases the sensitivity of the receptor to GABA. | ||||||
Muscimol | 2763-96-4 | sc-200460 sc-200460A | 5 mg 25 mg | $161.00 $537.00 | 2 | |
Muscimol is a GABA agonist found in the mushroom Amanita muscaria. It directly activates GABAA receptors, including those containing the Rα3 subunit, mimicking GABA's action and enhancing inhibitory neurotransmission. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine is an amino acid that can act as a positive allosteric modulator of GABAA receptors. It binds to a distinct site on the receptor, enhancing the receptor's response to GABA. This effect can include modulation of GABAA receptors containing the Rα3 subunit, contributing to increased inhibitory neurotransmission. | ||||||
(±)-Baclofen | 1134-47-0 | sc-200464 sc-200464A | 1 g 5 g | $56.00 $258.00 | ||
Although Baclofen is primarily a GABAB receptor agonist, it can indirectly influence GABAA receptor activity, including the Rα3 subunit. Its action on GABAB receptors can modulate downstream signaling pathways that affect GABAA receptor function, leading to changes in inhibitory neurotransmission. | ||||||