ZNF763 Inhibitors
Chemical inhibitors of ZNF763 function through various mechanisms that affect different pathways and cellular processes. For instance, A-443654 and GSK690693 target the Akt pathway, a crucial signaling route that influences numerous cellular functions, including those associated with ZNF763. By inhibiting Akt, these chemicals prevent the phosphorylation of downstream substrates and transcription factors, which are essential for the functional activity of ZNF763. Similarly, LY294002, a PI3K inhibitor, acts upstream of Akt, leading to reduced Akt activity and subsequent diminishment of ZNF763 functionality. PF-4708671 specifically inhibits S6 Kinase 1, which operates downstream of the mTOR pathway. The mTOR pathway is integral to protein synthesis and cell growth, and by hindering S6K1, PF-4708671 indirectly hampers the cellular processes vital for ZNF763's functions.
Furthermore, the MEK inhibitors PD98059 and U0126 attenuate the MAPK/ERK signaling pathway, which could be involved in regulating the activity of ZNF763. By reducing ERK pathway signaling, these inhibitors may limit the activation of transcription factors that govern ZNF763's activity. Alsterpaullone targets cyclin-dependent kinases, which are pivotal in cell cycle control, thus potentially inhibiting ZNF763 by altering the phosphorylation state of proteins that regulate its function. MG132, a proteasome inhibitor, causes an accumulation of ubiquitinated proteins which can interfere with the normal protein degradation process, possibly leading to an indirect inhibition of ZNF763 activity. Additionally, chemicals like SB203580 and SP600125 target other MAP kinases such as p38 and JNK, respectively. These kinases are part of stress response pathways and can affect transcriptional regulation, which may be necessary for ZNF763's proper function. Lastly, Y-27632 inhibits ROCK, which can disrupt the actin cytoskeleton organization and thus potentially interfere with the cellular infrastructure required for ZNF763's activity, while Rapamycin inhibits mTOR, thereby suppressing cell growth and protein synthesis processes crucial for ZNF763.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-443654 | 552325-16-3 | sc-507339 | 1 mg | $140.00 | ||
A-443654 inhibits Akt, which in turn is known to phosphorylate a wide range of substrates including transcription factors that could regulate ZNF763. Inhibition of Akt by A-443654 would prevent the phosphorylation of these transcription factors, potentially leading to reduced transcription factor activity and thereby inhibiting the functional activity of ZNF763. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $175.00 $700.00 | 9 | |
PF-4708671 specifically inhibits S6 Kinase 1 (S6K1), which is downstream of the mTOR signaling pathway. Since mTOR is a central regulator of protein synthesis and cell growth, the inhibition of S6K1 can lead to a decrease in the cellular processes that are necessary for ZNF763 function, thereby functionally inhibiting ZNF763 by reducing the resources it requires for its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK influences numerous transcription factors and cell signaling pathways. By inhibiting JNK, SP600125 can prevent the activation of transcription factors that may be necessary for the proper function of ZNF763, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which is upstream of the Akt pathway. Inhibition of PI3K by LY294002 would lead to a downregulation of Akt activity, reducing the phosphorylation of downstream targets that may interact with or regulate ZNF763, resulting in its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 can reduce ERK pathway signaling, which may be involved in the regulation of gene expression and transcription factors that influence the activity of ZNF763, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which is involved in stress responses and cellular signaling. Inhibition of p38 MAPK by SB203580 can alter the signaling pathways and transcriptional regulation mechanisms that ZNF763 may be involved in, thereby functionally inhibiting the protein. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, similar to PD98059, which works to inhibit ERK activation. By blocking MEK, U0126 can downregulate the MAPK/ERK pathway, potentially inhibiting the function of ZNF763 by attenuating the pathways and transcription factors that regulate its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and by inhibiting mTOR, it can suppress the mTORC1 complex, which is a critical regulator of cell growth and protein synthesis. This suppression can lead to the functional inhibition of ZNF763 by impeding the cellular processes that are essential for its protein function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK, which affects the organization of the actin cytoskeleton. Since the actin cytoskeleton can influence various cellular processes including signaling pathways and transcription factor localization, inhibition of ROCK by Y-27632 can lead to functional inhibition of ZNF763 by disrupting the cellular infrastructure it relies on for its activity. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is an Akt inhibitor, and similar to A-443654, it prevents the activation of Akt-dependent pathways. By inhibiting Akt, GSK690693 can reduce the phosphorylation and activity of downstream proteins and transcription factors that may be required for ZNF763 functionality, leading to its inhibition. | ||||||