ZNF518 Inhibitors
ZNF518 inhibitors encompass a range of chemical compounds that exert their inhibitory effects through various biochemical mechanisms. For instance, kinase inhibition by specific compounds results in the disruption of phosphorylation processes within the cell, which are critical for the proper functioning of zinc finger proteins like ZNF518. Phosphorylation alters the activity and interactions of ZNF518, and inhibitors that target kinases can therefore indirectly decrease ZNF518's functional activity. Similarly, inhibition of the proteasome system by other compounds leads to the stabilization and accumulation of proteins within the ubiquitin-proteasome pathway. This accumulation may sequester ZNF518, hindering its activity. Furthermore, compounds that inhibit DNA methyltransferase enzymes cause changes in the methylation status of DNA, which can lead to altered gene expression and indirectly affect the activity of ZNF518.
Other inhibitors target key signaling pathways such as the MAPK/ERK and PI3K pathways, which are essential for the regulation of various cellular processes, including those involving zinc finger proteins. By blocking these pathways, inhibitors can alter the phosphorylation state of proteins that interact with ZNF518, thereby diminishing its activity. In addition, inhibition of mTOR can affect protein translation, reducing the expression of proteins that regulate or interact with ZNF518. Cell cycle progression is also influenced by some inhibitors, which can impact the availability of cofactors or proteins that are necessary for ZNF518's function during cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that indirectly inhibits ZNF518 by inhibiting phosphorylation processes within cells that are necessary for the functional activity of certain zinc finger proteins. This leads to a reduction in ZNF518's activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that prevents the degradation of proteins involved in the ubiquitin-proteasome pathway. By stabilizing this system, it can lead to an accumulation of proteins that may sequester ZNF518, reducing its functional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that causes hypomethylation of DNA and may alter the expression of genes that regulate ZNF518, leading to its decreased functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that blocks the MAPK/ERK pathway, possibly altering the phosphorylation state of proteins that interact with ZNF518, thereby reducing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can disrupt signaling pathways which may indirectly lead to decreased activity or expression of ZNF518 by affecting transcription factors or coactivators that regulate the zinc finger protein. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
A Raf kinase inhibitor that can dampen the MAPK/ERK signaling, potentially disrupting the phosphorylation status of proteins that modulate the activity of ZNF518. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can indirectly reduce the activity of ZNF518 by affecting the translation of proteins that interact with or regulate the zinc finger protein. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
A cyclin-dependent kinase inhibitor that may affect cell cycle progression and thus decrease the activity of ZNF518 by altering the availability of cofactors or proteins that interact with ZNF518 during the cell cycle. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
An inhibitor of transcription factor activity that could decrease the expression of proteins that regulate the functional activity of ZNF518, leading to its indirect inhibition. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) that disrupts calcium homeostasis, which may affect proteins that interact with ZNF518, ultimately reducing its activity. | ||||||