ZNF441 Inhibitors
Chemical inhibitors of ZNF441 can act through various mechanisms to hinder its activity. Staurosporine is known for its capacity to broadly inhibit protein kinases, which includes those responsible for the phosphorylation of proteins like ZNF441, leading to a reduction in its activity that relies on phosphorylation. LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases (PI3K), can suppress the phosphorylation of downstream targets within the PI3K-AKT signaling pathway, a route that may be crucial for the regulation and proper functioning of ZNF441. Similarly, Rapamycin's inhibitory action on mTOR signaling could disrupt essential cellular processes and signaling pathways, which are necessary for the functional activity of ZNF441.
Furthermore, U0126 and PD98059 are selective inhibitors of MEK1/2, which play a pivotal role in the MAPK signaling pathway. Interference with this pathway can lead to decreased activation of downstream proteins that may be crucial for ZNF441's activity. In parallel, SP600125 targets JNK enzymes, leading to a decrease in the phosphorylation of regulatory proteins that may control the function of ZNF441. SB203580's selective inhibition of p38 MAPK also disrupts pathways that contribute to the functional activity of ZNF441. Dasatinib, through its inhibition of Src family kinases, can prevent phosphorylation of substrates involved in signaling pathways governing ZNF441 activity. H-89, a potent inhibitor of protein kinase A (PKA), can reduce phosphorylation of proteins that regulate ZNF441 function. Chelerythrine, which inhibits protein kinase C (PKC), can similarly reduce phosphorylation of crucial regulatory proteins for ZNF441. Lastly, Bortezomib, by inhibiting the proteasome pathway, can lead to an increase in proteins that negatively regulate ZNF441, thereby indirectly inhibiting its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can inhibit a broad range of protein kinases, which could include kinases that phosphorylate ZNF441, leading to a decrease in its phosphorylation-dependent activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K), which may reduce the phosphorylation of downstream targets that could be involved in the functional regulation of ZNF441, thereby inhibiting its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor that interferes with the PI3K-AKT signaling pathway, potentially diminishing the phosphorylation and subsequent activity of proteins that interact with ZNF441, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits mTOR, which is a key regulator of cell growth and proliferation. Inhibition of mTOR could disrupt cellular processes and signaling pathways that are necessary for the functional activity of ZNF441. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 selectively inhibits MEK1/2 which are upstream of ERK in the MAPK signaling pathway. Disruption of this pathway can decrease activation of downstream proteins that may be required for the functional activity of ZNF441. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which interferes with the MEK/ERK pathway. By inhibiting this pathway, PD98059 can reduce the phosphorylation of proteins that may be involved in the regulation of ZNF441 activity, resulting in its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits JNK, which can decrease the phosphorylation of regulatory proteins that are potentially involved in controlling ZNF441 activity, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. By inhibiting p38 MAPK, SB203580 could disrupt signaling pathways that contribute to the functional activity of ZNF441, resulting in its inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor, which may inhibit the phosphorylation of substrates involved in the signaling pathways that regulate the activity of ZNF441, thus inhibiting its function. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is an inhibitor of protein kinase C (PKC). By inhibiting PKC, chelerythrine could reduce the phosphorylation of proteins that are crucial for the functional regulation of ZNF441, leading to its inhibition. | ||||||