ZNF431 Activators
ZNF431 can initiate a diverse range of intracellular signaling pathways that result in its functional activation. Forskolin, by directly stimulating adenylyl cyclase, elevates intracellular levels of cAMP, which in turn activates protein kinase A (PKA). Activated PKA can then phosphorylate various substrates, including transcription factors that regulate the activity of ZNF431. Similarly, Dibutyryl-cAMP and 8-Bromo-cAMP, as cell-permeable cAMP analogs, also activate PKA and promote phosphorylation events that can lead to ZNF431 activation. Isoproterenol further contributes to this pathway by acting as a beta-adrenergic agonist, increasing cAMP levels and subsequently activating PKA, which can have downstream effects on ZNF431. On another front, PMA activates protein kinase C (PKC), which is implicated in phosphorylating proteins that may interact with or regulate ZNF431.
ZNF431 is also influenced by pathways that involve calcium signaling. Ionomycin and A23187 (Calcimycin), both calcium ionophores, elevate intracellular calcium levels. This increase in calcium can activate calmodulin-dependent kinase (CaMK), which in turn may play a role in the phosphorylation and activation of ZNF431. Epidermal Growth Factor (EGF) triggers the activation of EGFR tyrosine kinase, leading to downstream signal cascades like the MAPK/ERK pathway, affecting numerous proteins, which may include those that modulate ZNF431 activity. Hydrogen peroxide, as an oxidative signaling molecule, influences various kinases and can change the redox state of cells, which may indirectly influence the activation state of ZNF431. Anisomycin, although primarily a protein synthesis inhibitor, can also activate stress-activated protein kinases such as JNK, which might phosphorylate transcription factors that regulate ZNF431. Lastly, S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, which can increase cGMP levels and activate PKG, possibly influencing the phosphorylation state and activity of ZNF431.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which is involved in various signal transduction pathways. PKC activation can lead to the phosphorylation of transcription factors or other proteins that can enhance the functional activity of ZNF431 through downstream effects in the signaling pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may then phosphorylate and activate proteins, potentially including ZNF431, as part of the calcium signaling pathway. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can result in a cascade of phosphorylation events. This pathway may activate ZNF431 through downstream effects, such as the modification of transcription factors that regulate the protein's activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide serves as a signaling molecule that can modulate tyrosine phosphatase activity and promote the activation of various kinases. As an oxidative agent, it may contribute to the activation of ZNF431 by altering the redox state of cells and influencing signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor which can also activate stress-activated protein kinases like JNK. JNK activation can lead to the phosphorylation of transcription factors that might influence the activity of ZNF431 through stress response pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. By mimicking cAMP, it can activate PKA and potentially lead to the phosphorylation of proteins and transcription factors that regulate the activity of ZNF431 as part of the cAMP signaling pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels in cells, leading to PKA activation. Through PKA, isoproterenol can promote the phosphorylation of proteins that may result in the functional activation of ZNF431 within the adrenergic signaling context. | ||||||
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | sc-203279 sc-203279A | 5 g 10 g | $84.00 $122.00 | 9 | |
SNAP releases nitric oxide (NO), a signaling molecule that can activate guanylyl cyclase and increase cGMP levels. This may lead to the activation of PKG, which could phosphorylate proteins and influence transcription factors, potentially enhancing the functional activity of ZNF431. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is another cell-permeable cAMP analog that activates PKA. It can initiate the same cascade as cAMP, leading to the activation of PKA and the subsequent phosphorylation of proteins that may upregulate the functional activity of ZNF431. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore similar to ionomycin. It increases intracellular calcium levels, which can activate calcium-dependent signaling pathways, including the activation of CaMK. This can potentially lead to the activation of ZNF431 through calcium-mediated signaling processes. | ||||||