ZNF426 Activators
ZNF426 can modulate its activity through various intracellular signaling pathways that converge on the phosphorylation of proteins. Forskolin, by directly stimulating adenylate cyclase, increases the levels of cAMP within cells, which can lead to the activation of protein kinase A (PKA). PKA then has the capacity to phosphorylate a broad range of targets, including those that may interact with or be part of the regulatory network of ZNF426. This cascade of events enhances the DNA-binding activity of ZNF426 or its interaction with other co-regulatory proteins. Similarly, agents like 8-Br-cAMP and Dibutyryl-cAMP, being membrane-permeable analogs of cAMP, also activate PKA and thus can contribute to the phosphorylation and subsequent activation of ZNF426. IBMX, by inhibiting phosphodiesterases and preventing cAMP breakdown, indirectly supports sustained PKA activity, which can further modulate ZNF426 activity.
cAMP-PKA axis, other signaling molecules like PMA and Bryostatin 1 activate protein kinase C (PKC), which can initiate a phosphorylation cascade potentially affecting ZNF426. Ionomycin and A23187, as calcium ionophores, raise intracellular calcium levels, thereby activating calcium-dependent kinases such as calmodulin-dependent kinase (CaMK). CaMK can phosphorylate transcription factors or cofactors that modulate ZNF426 activity. Thapsigargin, a SERCA pump inhibitor, also leads to increased cytosolic calcium, similarly facilitating the activation of kinases that can phosphorylate and impact the activity of ZNF426. Anisomycin, while inhibiting protein synthesis, activates stress-activated protein kinases such as JNK, which may phosphorylate regulatory elements linked to ZNF426. Lastly, inhibitors of protein phosphatases like Calyculin A and Okadaic Acid, by preventing the dephosphorylation of proteins, result in a net increase in the phosphorylated state of cellular proteins, which can include those associated with the regulation and activation of ZNF426.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP levels can lead to the activation of protein kinase A (PKA). PKA can phosphorylate various targets including transcription factors which may lead to the activation of ZNF426 by enhancing its DNA-binding activity or its interaction with other co-regulators in the cell. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog which activates PKA. By activating PKA, this compound can phosphorylate substrates that may include factors involved in the regulatory network of ZNF426, thereby promoting its activation directly or facilitating its function in gene regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, which hydrolyze cAMP and cGMP. By preventing the breakdown of cAMP, IBMX indirectly increases PKA activity, which potentially phosphorylates and activates ZNF426 or components of its regulatory network. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC). PKC activation can lead to a cascade of phosphorylation events affecting various proteins including transcription factors or cofactors that could enhance the activity or stability of ZNF426, thus leading to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may then phosphorylate transcription factors or other regulatory proteins that modulate the activity of ZNF426, leading to its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels. This increase in calcium can activate pathways similar to ionomycin, including the potential activation of CaMK and subsequent phosphorylation of regulatory elements associated with ZNF426, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that is more membrane-permeable than cAMP itself. It activates PKA, leading to phosphorylation of proteins within the cell. This phosphorylation event can include modulating proteins that interact with ZNF426, thereby activating it. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor which leads to an increase in cytosolic calcium levels. Increased calcium can activate CaMK or other calcium-dependent proteins that could phosphorylate and activate ZNF426 or proteins within its regulatory network. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is an activator of PKC. By activating PKC, it can influence the phosphorylation status of proteins involved in the regulation of ZNF426, potentially leading to its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases like JNK. Activation of JNK can lead to the phosphorylation of transcription factors or regulatory proteins that could activate ZNF426 through direct or indirect interactions. | ||||||