ZNF329 Activators
ZNF329 activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of ZNF329 through distinct signaling pathways and molecular mechanisms. Forskolin, by augmenting cAMP levels, indirectly potentiates ZNF329's transcriptional regulation by stimulating PKA, which may phosphorylate transcription factors to facilitate ZNF329-target gene interactions. Trichostatin A and Sodium butyrate, as HDAC inhibitors, foster a chromatin context conducive to ZNF329's access to DNA by increasing histone acetylation, potentially amplifying its gene regulatory influence. The DNA methylation inhibitor 5-Azacytidine can similarly promote the transcriptional endeavors of ZNF329 by decreasing methylation at gene promoters, thereby enhancing ZNF329's binding efficiency. In addition, Ionomycin's role in elevating intracellular calcium and Retinoic acid's activation of nuclear receptors may lead to post-translational modifications of ZNF329 or its associated factors, further refining its capacity to modulate gene expression.
The activity of ZNF329 is also supported by compounds that impact various kinase pathways. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which could phosphorylate intermediaries that positively regulate ZNF329's function. Conversely, Epigallocatechin gallate (EGCG) and LY294002 serve as kinase inhibitors, potentially alleviating negative regulatory influences on ZNF329, thus endorsing its transcriptional activity. The methylation facilitator S-Adenosylmethionine could enhance ZNF329's regulatory potential by altering histone methylation patterns conducive to its action. Furthermore, SP600125, as a JNK inhibitor, may elevate ZNF329's regulatory function by modifying the activity of transcriptional co-regulators.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator, leading to increased cAMP levels. cAMP acts as a second messenger activating protein kinase A (PKA). PKA can phosphorylate transcription factors, which may enhance the transcriptional regulatory functions of ZNF329 by promoting its binding to gene promoters. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. By increasing the acetylation of histones, it promotes a more relaxed chromatin structure, which can enhance the binding of transcription factors like ZNF329 to DNA, potentially increasing its functional activity in gene regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It reduces DNA methylation, which can lead to gene activation. Lowered methylation levels may enhance the access of ZNF329 to its target gene promoters, thereby increasing its regulatory activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent protein kinase C (PKC) activator. Activated PKC can phosphorylate numerous targets, which could include factors that interact with or modify the activity of ZNF329, potentially enhancing its role in gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor with multiple targets. By inhibiting kinases that may compete with or negatively regulate ZNF329, EGCG could enhance the activity of ZNF329 by reducing these regulatory interactions, thus promoting ZNF329's role in transcriptional regulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent phosphatases and kinases, which might modify ZNF329 or its co-factors, potentially enhancing the regulatory function of ZNF329 in gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts as a ligand for nuclear receptors that can heterodimerize with other transcription factors. Such interactions could influence the activity of ZNF329 by altering its binding affinity or specificity to DNA, thus modulating its gene regulatory functions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is an HDAC inhibitor, similar to Trichostatin A. By promoting histone acetylation and a relaxed chromatin state, sodium butyrate can enhance the accessibility of ZNF329 to its target sites in DNA, potentially increasing its transcriptional regulatory activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor in biological transmethylation reactions. It can contribute to the methylation of histones, which could affect ZNF329 activity by altering chromatin structure and transcription factor accessibility in a way that enhances ZNF329's ability to regulate gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, LY294002 can modulate downstream signaling pathways that may indirectly enhance the activity of ZNF329 by affecting the phosphorylation state of proteins that interact with ZNF329, influencing its transcriptional regulatory functions. | ||||||