Date published: 2025-10-23

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ZNF329 Activators

ZNF329 activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of ZNF329 through distinct signaling pathways and molecular mechanisms. Forskolin, by augmenting cAMP levels, indirectly potentiates ZNF329's transcriptional regulation by stimulating PKA, which may phosphorylate transcription factors to facilitate ZNF329-target gene interactions. Trichostatin A and Sodium butyrate, as HDAC inhibitors, foster a chromatin context conducive to ZNF329's access to DNA by increasing histone acetylation, potentially amplifying its gene regulatory influence. The DNA methylation inhibitor 5-Azacytidine can similarly promote the transcriptional endeavors of ZNF329 by decreasing methylation at gene promoters, thereby enhancing ZNF329's binding efficiency. In addition, Ionomycin's role in elevating intracellular calcium and Retinoic acid's activation of nuclear receptors may lead to post-translational modifications of ZNF329 or its associated factors, further refining its capacity to modulate gene expression.

The activity of ZNF329 is also supported by compounds that impact various kinase pathways. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which could phosphorylate intermediaries that positively regulate ZNF329's function. Conversely, Epigallocatechin gallate (EGCG) and LY294002 serve as kinase inhibitors, potentially alleviating negative regulatory influences on ZNF329, thus endorsing its transcriptional activity. The methylation facilitator S-Adenosylmethionine could enhance ZNF329's regulatory potential by altering histone methylation patterns conducive to its action. Furthermore, SP600125, as a JNK inhibitor, may elevate ZNF329's regulatory function by modifying the activity of transcriptional co-regulators.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin is an adenylate cyclase activator, leading to increased cAMP levels. cAMP acts as a second messenger activating protein kinase A (PKA). PKA can phosphorylate transcription factors, which may enhance the transcriptional regulatory functions of ZNF329 by promoting its binding to gene promoters.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A is a histone deacetylase (HDAC) inhibitor. By increasing the acetylation of histones, it promotes a more relaxed chromatin structure, which can enhance the binding of transcription factors like ZNF329 to DNA, potentially increasing its functional activity in gene regulation.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine is a DNA methyltransferase inhibitor. It reduces DNA methylation, which can lead to gene activation. Lowered methylation levels may enhance the access of ZNF329 to its target gene promoters, thereby increasing its regulatory activity.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA is a potent protein kinase C (PKC) activator. Activated PKC can phosphorylate numerous targets, which could include factors that interact with or modify the activity of ZNF329, potentially enhancing its role in gene regulation.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG is a kinase inhibitor with multiple targets. By inhibiting kinases that may compete with or negatively regulate ZNF329, EGCG could enhance the activity of ZNF329 by reducing these regulatory interactions, thus promoting ZNF329's role in transcriptional regulation.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent phosphatases and kinases, which might modify ZNF329 or its co-factors, potentially enhancing the regulatory function of ZNF329 in gene expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid acts as a ligand for nuclear receptors that can heterodimerize with other transcription factors. Such interactions could influence the activity of ZNF329 by altering its binding affinity or specificity to DNA, thus modulating its gene regulatory functions.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Sodium butyrate is an HDAC inhibitor, similar to Trichostatin A. By promoting histone acetylation and a relaxed chromatin state, sodium butyrate can enhance the accessibility of ZNF329 to its target sites in DNA, potentially increasing its transcriptional regulatory activity.

Ademetionine

29908-03-0sc-278677
sc-278677A
100 mg
1 g
$180.00
$655.00
2
(1)

S-Adenosylmethionine serves as a methyl donor in biological transmethylation reactions. It can contribute to the methylation of histones, which could affect ZNF329 activity by altering chromatin structure and transcription factor accessibility in a way that enhances ZNF329's ability to regulate gene expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor. By inhibiting PI3K, LY294002 can modulate downstream signaling pathways that may indirectly enhance the activity of ZNF329 by affecting the phosphorylation state of proteins that interact with ZNF329, influencing its transcriptional regulatory functions.