ZNF239 Inhibitors
ZNF239 inhibitors encompass a diverse range of chemical compounds that impede the functional activity of this zinc finger protein through various biochemical pathways. For instance, the activity of ZNF239 can be indirectly inhibited by compounds that target protein kinases. These inhibitors prevent the phosphorylation of key proteins that ZNF239 may require for its role in gene expression regulation. Specifically, the inhibition of signaling pathways such as the MAPK/ERK pathway, where ZNF239 is implicated, results in a diminished regulatory capacity of ZNF239 on gene transcription processes. Another subset of inhibitors disrupts the PI3K/AKT signaling axis, which could intersect with ZNF239's putative involvement in transcriptional regulation through DNA binding. Similarly, compounds that inhibit mTOR signaling can impede cellular processes that may affect ZNF239's ability to regulate gene expression related to cell growth and proliferation.
Moreover, inhibitors that act on the JNK and p38 MAPK can modify the activity of transcription factors and stress response genes, potentially leading to a decreased activity of ZNF239 if it interacts with these pathways. Furthermore, proteasome inhibitors can alter the stability of proteins that regulate ZNF239's activity, thereby affecting its functional state. In addition, compounds that influence cytoskeleton organization and cell adhesion processes can indirectly modulate ZNF239's activity. This is based on the premise that ZNF239's function could be tied to these cellular processes. Lastly, inhibitors that target transcription factors such as NF-κB could lead to changes in the expression of genes that are either regulated by ZNF239 or are part of a co-regulatory network, thus impeding ZNF239's regulatory influence on gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This alkaloid acts as a potent inhibitor of protein kinases. It prevents the phosphorylation of proteins, which is a critical post-translational modification that ZNF239 may require for its functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As a specific inhibitor of MEK, which acts upstream in the MAPK/ERK pathway, PD 98059 disrupts the signaling that could be necessary for ZNF239 function related to gene expression regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This compound inhibits PI3 kinase, potentially altering AKT signaling, which may intersect with pathways that ZNF239 is involved in, particularly those related to DNA binding and transcriptional regulation. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
It inhibits Raf kinase, which is part of the MAPK pathway. By inhibiting this pathway, it may indirectly inhibit ZNF239 activity, assuming ZNF239 is involved in gene expression processes regulated by this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in the control of cell growth and proliferation, processes that may affect the function of ZNF239 in gene regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
This selective inhibitor of MEK1/2 disrupts the MAPK/ERK pathway, which could have downstream effects on ZNF239 activity if ZNF239 is involved in signaling pathways that regulate gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
This compound inhibits JNK, which could reduce the activity of transcription factors and potentially affect the function of ZNF239 if it interacts with these transcription factors. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 MAPK, which could lead to the inhibition of ZNF239 activity if ZNF239's function is associated with stress response genes regulated by p38 MAPK. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of regulatory proteins, potentially affecting ZNF239's activity if it is stabilized by such proteins. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
This inhibitor of ROCK kinase could impact cytoskeleton organization and cell adhesion, which might indirectly affect ZNF239 if its activity is linked to these cellular processes. | ||||||