ZMYM1 Activators
ZMYM1 activators represent a specialized set of chemical compounds that bolster the functional activity of ZMYM1 through various cellular signaling mechanisms. The activation begins with agents like Forskolin, 8-Bromo-cAMP, and IBMX, which enhance the cAMP-dependent pathway. Forskolin directly stimulates adenylyl cyclase, thereby raising cAMP levels that activate protein kinase A (PKA). PKA then potentially phosphorylates ZMYM1, augmenting its regulatory role in gene expression. Additionally, 8-Bromo-cAMP, a cAMP analog, and IBMX, a phosphodiesterase inhibitor, perpetuate PKA activation, further promoting ZMYM1's activity. Meanwhile, PMA, by triggering protein kinase C (PKC), and Lithium chloride, by inhibiting GSK-3, may modulate proteins that interact with ZMYM1, potentially enhancing its functionality in chromatin remodeling processes.
Concurrently, epigenetic modulators such as Epigallocatechin gallate, Sodium butyrate, Trichostatin A, and 5-Azacytidine reshape the chromatin landscape, which is integral to ZMYM1's function. Epigallocatechin gallate inhibits DNA methyltransferases, possibly leading to a chromatin state that favors ZMYM1 activity. Sodium butyrate and Trichostatin A, both histone deacetylase inhibitors, induce a more open chromatin conformation, potentially facilitating ZMYM1's engagement with gene regulatory regions. Furthermore, Retinoic acid, by modulating gene expression via its receptors, may create a favorable environment for ZMYM1's functional enhancement. These compounds, by altering the epigenetic context in which ZMYM1 operates, indirectly enhance its role in the precise orchestration of gene expression, without altering its own expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby enhance the activity of various proteins, potentially including ZMYM1, by altering its interaction with transcriptional machinery. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA phosphorylation can modify the conformation and function of target proteins, including ZMYM1, to enhance their activity in gene regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which could enhance ZMYM1 activity through phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit DNA methyltransferases, potentially leading to altered expression patterns of various genes. This could indirectly enhance ZMYM1's role in chromatin remodeling and gene expression regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, which can deacetylate histones and non-histone proteins, potentially modifying ZMYM1 function and enhancing its activity in gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is a histone deacetylase inhibitor that causes hyperacetylation of histones, which can alter gene expression. This could indirectly enhance ZMYM1's activity by changing the chromatin structure it interacts with. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors and alters gene expression. This can lead to changes in chromatin structure that indirectly enhance the activity of ZMYM1 in regulating gene transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, leading to increased acetylation of histones and affecting gene expression. Enhanced acetylation could indirectly affect ZMYM1 function in chromatin organization and gene regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By altering DNA methylation patterns, it can affect chromatin structure and gene expression, potentially enhancing the functional activity of ZMYM1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a broad range of substrates, including proteins that may interact with ZMYM1, thereby potentially enhancing its activity. | ||||||