Zic1 Inhibitors
Zic1 inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of the zinc finger transcription factor Zic1. The Zic family of proteins plays a crucial role in the regulation of embryonic development, cell differentiation, and tissue patterning. Zic1, in particular, has been identified as a key player in various cellular processes, including neurogenesis and axial patterning during early embryonic development. By selectively inhibiting the function of Zic1, these inhibitors aim to elucidate the intricate regulatory mechanisms underlying these biological processes.
The molecular structure of Zic1 inhibitors is characterized by their ability to bind specifically to the active site of the Zic1 protein, thereby interfering with its transcriptional activity. Typically, these inhibitors are small molecules with well-defined chemical structures, allowing for precise interactions with the target protein. The development of Zic1 inhibitors involves a thorough understanding of the three-dimensional structure of the Zic1 protein, enabling medicinal chemists to design compounds that can effectively disrupt its function. This class of compounds holds promise as valuable research tools for investigating the fundamental molecular mechanisms.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Inhibits the Hedgehog (Hh) signaling pathway, which may intersect with ZIC1 during embryonic development and differentiation. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Targets the Hedgehog pathway at the level of the Smoothened receptor, which indirectly could alter ZIC1 activity. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
Specifically inhibits GLI transcription factors in the Hedgehog pathway, potentially affecting ZIC1-related processes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Disrupts the interaction of BET bromodomains with acetylated histones, potentially modulating ZIC1 expression. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
BET bromodomain inhibitor, could decrease transcriptional regulation involving ZIC1 by altering chromatin accessibility. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
CDK4/6 inhibitor, can indirectly influence ZIC1 by altering cell cycle progression and thus the cellular context of ZIC1. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2 antagonist, stabilizing p53, which can then affect ZIC1 expression as part of the p53 transcriptional program. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A selective p300/CBP histone acetyltransferase inhibitor, potentially impacting ZIC1 transcriptional activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor, may increase the levels of proteins that interact with or regulate ZIC1, modifying its activity. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
BMP receptor inhibitor, could alter developmental pathways in which ZIC1 is involved. | ||||||