ZFX Inhibitors
ZFX inhibitors predominantly focus on modulating transcriptional activity, either directly or through influencing associated pathways. α-Amanitin directly targets RNA polymerase II, reducing its transcriptional activity, while Actinomycin D intercalates within DNA to prevent transcription. DRB affects transcription elongation by inhibiting P-TEFb, which is vital for RNA polymerase II's release. Flavopiridol's target is the cyclin-dependent kinases, which are crucial for transcriptional regulation. JQ1 and I-BET762, on the other hand, inhibit BET bromodomains, including BRD4, which is an essential regulator of transcription.
Triptolide has a broader range of action, affecting multiple transcription factors and RNA polymerase II. SAHA, as an HDAC inhibitor, impacts chromatin remodeling, which indirectly regulates transcription. Pladienolide B and H3B-8800 modulate the SF3b complex, impacting splicing and subsequently transcription. Isoginkgetin inhibits the spliceosome assembly, affecting mRNA processing, while Cortistatin A hinders the mediator complex recruitment, affecting transcription initiation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Inhibits RNA polymerase II, thus reducing transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Intercalates DNA, preventing transcription. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits the activity of positive transcription elongation factor b (P-TEFb), a key player in the release of RNA polymerase II. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Inhibits cyclin-dependent kinases, thus affecting transcriptional regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Inhibits BET bromodomains, including BRD4, which regulates transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Affects multiple transcription factors and inhibits RNA polymerase II activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Histone deacetylase (HDAC) inhibitor affecting chromatin remodeling and transcription. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Inhibits the SF3b complex, impacting splicing and indirectly affecting transcription. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Inhibits the assembly of the spliceosome, affecting mRNA processing and transcription indirectly. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
Inhibits BET bromodomains which play roles in transcription regulation. | ||||||