Zfp870 Inhibitors
Zfp870, a zinc finger protein, is characterized by its involvement in DNA-binding transcription factor activity, specifically with RNA polymerase II and cis-regulatory region sequence-specific DNA binding. Predicted to regulate transcription by RNA polymerase II, Zfp870 is primarily active in the nucleus and expressed in the nervous system and neural retina.
Inhibition of Zfp870 can be achieved through various chemical entities targeting key cellular processes. Direct inhibitors, such as Actinomycin D and Triptolide, impact RNA polymerase II activity, directly interfering with Zfp870's DNA-binding functions. Indirect inhibitors, like Flavopiridol and Trichostatin A, influence Zfp870 by disrupting cellular pathways related to transcription and chromatin structure. The specific biochemical mechanisms through which each inhibitor acts provide a nuanced understanding of Zfp870 inhibition, laying the groundwork for further exploration of targeted modulation in the context of transcriptional regulation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D, a potent transcription inhibitor, directly interferes with RNA polymerase II activity. By disrupting the transcriptional machinery, it indirectly inhibits Zfp870's DNA-binding and regulatory functions. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits RNA polymerase II-mediated transcription, directly impacting Zfp870's DNA-binding activity. This interference with RNA polymerase II indirectly inhibits Zfp870's transcriptional regulation. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol, a CDK inhibitor, directly disrupts the cell cycle and RNA polymerase II activity, indirectly inhibiting Zfp870. The inhibition of CDKs influences Zfp870's transcriptional regulation functions. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin, an RNA polymerase II inhibitor, directly hinders RNA polymerase II activity, affecting Zfp870's DNA-binding and regulatory functions. The disruption of RNA polymerase II directly inhibits Zfp870. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil, a thymidylate synthase inhibitor, indirectly influences Zfp870 by disrupting DNA synthesis. The inhibition of thymidylate synthase impacts Zfp870's ability to bind to cis-regulatory regions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, directly modulates chromatin structure, affecting Zfp870's access to cis-regulatory regions. The inhibition of HDACs indirectly impacts Zfp870's DNA-binding activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, indirectly affects Zfp870 by altering DNA topology. The inhibition of topoisomerase II influences Zfp870's DNA-binding and regulatory functions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, directly impacts DNA dynamics, indirectly inhibiting Zfp870. The disruption of topoisomerase I activity influences Zfp870's DNA-binding and regulatory functions. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a DNA cross-linker, indirectly affects Zfp870 by altering DNA structure. The modification of DNA structure impacts Zfp870's ability to bind to cis-regulatory regions, influencing its regulatory functions. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB, an RNA synthesis inhibitor, directly disrupts RNA polymerase II activity, impacting Zfp870's DNA-binding and regulatory functions. The inhibition of RNA synthesis affects Zfp870 function. | ||||||