Zfp867 Inhibitors
Zfp867 inhibitors belong to a class of compounds that target the Zinc finger protein 867 (Zfp867), a member of the large zinc finger protein family known for their role in DNA binding and gene regulation. Zinc finger proteins are characterized by their unique structural motifs that coordinate zinc ions to stabilize folds in the protein, which are necessary for their interaction with specific DNA sequences. Zfp867, like many other zinc finger proteins, is involved in transcriptional regulation, potentially affecting a wide range of biological processes. These inhibitors are designed to interfere with the function of Zfp867 by disrupting its ability to bind DNA or interact with other regulatory proteins, thereby modulating the gene expression pathways it influences. Through this interference, Zfp867 inhibitors can alter cellular signaling, protein synthesis, and other key molecular events in cells.
Structurally, Zfp867 inhibitors are often small molecules with precise chemical features that allow them to bind either to the zinc finger domain or to regions that affect Zfp867's conformational integrity. These interactions can vary in specificity and strength, depending on the design of the inhibitor and the molecular characteristics of Zfp867. Inhibitors may be designed to selectively bind to Zfp867's DNA recognition sequence or its co-regulatory protein partners, thus disrupting key protein-DNA or protein-protein interactions. The structural diversity of these inhibitors allows for fine-tuning of their binding properties, making them valuable for research into the regulatory mechanisms of transcriptional control. Additionally, studies into Zfp867 inhibitors can provide insights into the complex network of gene regulation mediated by zinc finger proteins, expanding the understanding of transcriptional modulation at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 directly inhibits Raf-1 kinase, which is involved in the MAPK/ERK signaling pathway. Zinc finger protein 867, as part of this pathway, relies on Raf-1 kinase mediated signaling for its activity. Inhibition of Raf-1 kinase by GW5074 would lead to inhibition of zinc finger protein 867 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which phosphorylates and activates ERK in the MAPK/ERK pathway. Zinc finger protein 867 activity is dependent on this pathway, so inhibition of MEK by PD98059 would result in decreased activation of ERK and subsequent inhibition of zinc finger protein 867. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinases (PI3K), which are upstream regulators of the Akt signaling pathway. This pathway can regulate the activity of various proteins, including zinc finger proteins. Thus, LY294002 inhibits zinc finger protein 867 by impeding the PI3K/Akt pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can activate several signaling pathways that may regulate zinc finger proteins. By inhibiting Src kinases, PP2 can inhibit downstream signaling that would otherwise contribute to the functional activity of zinc finger protein 867. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), which is involved in the stress-activated protein kinase pathway that can regulate transcription factors. Inhibition of JNK by SP600125 would thus inhibit downstream signaling that influences the activity of zinc finger protein 867. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, which is part of a signaling pathway that can impact transcription factors, including zinc finger proteins. The inhibition of p38 MAP kinase by SB203580 would inhibit the activity of zinc finger protein 867 through this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, similar to LY294002. By inhibiting PI3K, it impedes the PI3K/Akt pathway, which can regulate the activity of proteins, including zinc finger protein 867. Therefore, Wortmannin's inhibition of PI3K leads to inhibition of zinc finger protein 867 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central component of the PI3K/Akt/mTOR pathway, which regulates protein synthesis and cell growth. mTOR inhibition by Rapamycin would reduce signaling that could enhance the activity of zinc finger protein 867, thus functionally inhibiting it. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor with activity against Src family kinases. As these kinases can modulate signaling pathways involved in the regulation of zinc finger proteins, Dasatinib's inhibition of Src kinases would lead to inhibition of zinc finger protein 867 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2, which are upstream activators of ERKs in the MAPK/ERK signaling pathway. Inhibition of MEK1/2 by U0126 prevents the phosphorylation and activation of ERKs, inhibiting the signaling required for the activity of zinc finger protein 867. | ||||||