Zfp846 Activators
Chemical activators of zinc finger protein 846 can play a pivotal role in its functional activation by interacting with the protein's zinc finger motifs or by influencing its structural and functional integrity. Zinc sulfate, for instance, donates zinc ions that bind to zinc finger protein 846, crucial for maintaining the protein's conformation and enhancing its DNA-binding capability. This direct interaction with the zinc ions is critical for the protein's structural stability, which in turn is essential for its activation. Similarly, copper(II) sulfate and nickel(II) sulfate introduce copper and nickel ions, respectively, which can interact with the protein's binding sites. These metal ions may induce a conformational shift in zinc finger protein 846, leading to increased DNA-binding activity and thus promoting its functional activation. The presence of cobalt(II) chloride and manganese(II) chloride also serves as a source of cobalt and manganese ions, which can substitute for zinc in the protein's structure, potentially leading to an altered, yet active, conformation of the protein.
Moreover, cadmium chloride and mercury(II) chloride contribute cadmium and mercury ions, respectively, which could bind to zinc finger protein 846 and induce allosteric changes, thereby facilitating an enhanced activation of the protein's DNA-binding function. Lead(II) nitrate may also bind to the protein, influencing its structural domains and promoting an activation state conducive to its biological role. Additionally, lithium chloride can affect the phosphorylation status of kinases and phosphatases that interact with zinc finger protein 846, leading to activation through post-translational modifications that affect the protein's function. Magnesium chloride, sodium chloride, and potassium chloride are essential for maintaining the charge balance and structural integrity of the protein. Magnesium ions are particularly crucial for the zinc finger domains, while sodium and potassium ions help stabilize the charge distribution around the protein, which can facilitate the proper folding and function of zinc finger protein 846, ensuring that it remains in an active state capable of binding to DNA effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate provides zinc ions, which can bind to zinc finger protein 846, thereby stabilizing its structure and enhancing its ability to interact with DNA, leading to an increased activation of its DNA-binding function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate can provide copper ions that competitively interact with the zinc binding sites of zinc finger protein 846, which can result in a conformational change that potentially enhances its binding to DNA and subsequent activation of its function. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese(II) chloride supplies manganese ions that might bind to certain domains of zinc finger protein 846, potentially inducing structural changes that enhance the protein's activation and function in the cellular context. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt(II) chloride provides cobalt ions that can substitute for zinc in zinc finger protein 846, possibly leading to changes in the protein's conformation and an increase in its functional activity related to DNA binding. | ||||||
Nickel Sulfate | 7786-81-4 | sc-507407 | 5 g | $63.00 | ||
Nickel(II) sulfate can deliver nickel ions that may interact with the zinc finger motifs of zinc finger protein 846, potentially facilitating an active conformation of the protein that enhances its function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride provides cadmium ions that could bind to zinc finger protein 846, which may result in an allosteric activation of the protein, enhancing its interaction with target DNA sequences. | ||||||
Lead (II) nitrate | 10099-74-8 | sc-211724 sc-211724A | 100 g 500 g | $40.00 $88.00 | ||
Lead(II) nitrate can introduce lead ions that might bind to and influence the structural domains of zinc finger protein 846, potentially leading to an enhanced activation state of the protein. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can provide lithium ions that might influence the phosphorylation status of interacting kinases and phosphatases, leading to an activation of zinc finger protein 846 through post-translational modifications. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium chloride supplies magnesium ions that can be crucial for the structural integrity of the zinc finger domains of zinc finger protein 846, supporting its active conformation and function. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Sodium chloride provides sodium ions that might stabilize the charge distribution around zinc finger protein 846, potentially promoting its binding to DNA and enhancing functional activation. | ||||||