ZFP120 Inhibitors
Chemical inhibitors of ZFP120 can impact its function through various biochemical pathways. Alsterpaullone, a potent CDK inhibitor, disrupts the cell cycle, which can affect ZFP120 if its activity is tied to cell cycle events. Paullones, another group of CDK inhibitors, can similarly impact ZFP120 by blocking its cell cycle-dependent regulation or modification. Inhibition of the PI3K/Akt pathway by chemicals like wortmannin and LY294002 can decrease the phosphorylation state of several proteins, including ZFP120, thereby impeding its normal function. This pathway is crucial for multiple cellular processes, and its disruption can impinge upon the activity of proteins regulated by it.
Additionally, SP600125, a JNK inhibitor, can prevent the phosphorylation of JNK-regulated proteins, which includes ZFP120, leading to its functional inhibition by hindering activation through phosphorylation. SB203580 and U0126, which inhibit p38 MAP kinase and MEK1/2 respectively, can preclude the phosphorylation of ZFP120 if it is regulated by the p38 MAPK or the MEK-ERK pathway. Similarly, PD98059's inhibition of MEK can result in reduced activity of proteins downstream of ERK, possibly including ZFP120. Rapamycin's inhibition of mTOR can disrupt processes essential for ZFP120's functional activity. Y-27632, a ROCK inhibitor, can lead to changes in gene expression that might affect ZFP120 function if it is regulated by ROCK-mediated pathways. PP2, an inhibitor of Src family kinases, can impact ZFP120 by disrupting signaling cascades regulated by these kinases. Finally, triptolide can inhibit the activity of transcription factors and may disrupt the interaction of ZFP120 with other proteins or DNA elements required for its activity. Each of these inhibitors can interfere with critical signaling pathways and protein interactions that are necessary for the proper function of ZFP120 within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a potent inhibitor of cyclin-dependent kinases (CDKs) which are important for cell cycle regulation. By inhibiting CDKs, alsterpaullone can disrupt the cell cycle, which may lead to the functional inhibition of ZFP120 due to the protein's potential involvement in cell cycle-dependent processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a specific inhibitor of phosphoinositide 3-kinases (PI3K). PI3K is involved in many signaling pathways, including those regulating transcription factors and nuclear proteins. Inhibition of PI3K can alter the phosphorylation state of proteins associated with it, potentially leading to the functional inhibition of ZFP120 through disrupted signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Similar to wortmannin, LY294002 is a chemical inhibitor of PI3K. By inhibiting the PI3K/Akt pathway, LY294002 can lead to a decrease in the phosphorylation and activation of downstream proteins, which may include ZFP120, thereby inhibiting its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, SP600125 can prevent the phosphorylation of proteins regulated by JNK, which may include ZFP120. The inhibition of JNK signaling could therefore lead to the functional inhibition of ZFP120 by preventing its activation through phosphorylation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAP kinase, which is involved in stress and inflammatory responses. If ZFP120 is activated or regulated by p38 MAPK-mediated signaling, inhibition by SB203580 could functionally inhibit ZFP120 by preventing its phosphorylation and thus its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which is upstream of extracellular signal-regulated kinases (ERK). MEK-ERK pathway inhibition by PD98059 can lead to reduced activity of downstream proteins, potentially including ZFP120, thus functionally inhibiting its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR (mechanistic target of rapamycin), which is a central protein in a signaling pathway that regulates cell growth and proliferation. Through the inhibition of mTOR, rapamycin can disrupt processes that may be essential for the functional activity of ZFP120, leading to its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, and by inhibiting MEK, it prevents the activation of ERK, which may be involved in the regulation of ZFP120. As such, the inhibition of this pathway can result in the functional inhibition of ZFP120 by preventing its phosphorylation or other post-translational modifications that regulate its activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated protein kinase). ROCK is implicated in various cellular functions, including the regulation of transcriptional activity. Inhibition of ROCK by Y-27632 could lead to changes in the cytoskeleton and in gene expression that may functionally inhibit ZFP120 if it is regulated by ROCK-mediated pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases. Src kinases can influence various signaling pathways that regulate transcription factors and other nuclear proteins. Inhibition of Src family kinases by PP2 can lead to functional inhibition of ZFP120 if it is part of signaling cascades regulated by these kinases. | ||||||